Drug-induced liver injury (DILI) is one among the common adverse drug reactions and the
leading causes of drug development attritions, black box warnings, and post-marketing …

Non-alcoholic fatty liver disease encompasses a spectrum of liver diseases, including
simple steatosis, steatohepatitis, liver fibrosis and cirrhosis and hepatocellular carcinoma …

Bile duct obstruction is a potent stimulus for cholangiocyte proliferation, especially for large
cholangiocytes. Our previous studies reported that conjugated bile acids (CBAs) activate the …

Ethnopharmacological relevance Cholestatic liver disease (CLD) is mainly characterized by
cholestasis. If not treated, it will deteriorate to cholestatic hepatitis, liver fibrosis, liver …

Precision medicine, taking account of human individuality in genes, environment, and
lifestyle for early disease diagnosis and individualized therapy, has shown great promise to …

Maintenance of bile acid (BA) homeostasis is essential to achieve their physiologic functions
and avoid their toxic effects. The marked differences in BA composition between preclinical …

Cholestatic drug‐induced liver injury (DILI) induced by drugs or other xenobiotics is a severe
and even fatal clinical syndrome. Here, living materials of hierarchy‐assembled dual …

Introduction Atogepant is a selective calcitonin gene-related peptide (CGRP) receptor
antagonist that is utilized in adults for the prevention of episodic and chronic migraine …

Ethnopharmacological relevance The liver toxicity of Reynoutria multiflora (Thunb.)
Moldenke.(Polygonaceae)(Polygonum multiflorum Thunb, PM) has always attracted much …

In recent years, there has been a plethora of attempts to discover biomarkers that are more
reliable than α-fetoprotein for the early prediction and prognosis of hepatocellular carcinoma …