Major depression and anxiety disorders have high prevalence rates and are frequently
comorbid. The neurobiological bases for these disorders are not fully understood, and …

Essential polyunsaturated fatty acids (PUFAs) have profound effects on brain development
and function. Abnormalities of PUFA status have been implicated in neuropsychiatric …

Antidepressants increase adult hippocampal neurogenesis in animal models, but the
underlying molecular mechanisms are unknown. In this study, we used human hippocampal …

Psychiatric disorders like mood disorders, schizophrenia, or drug addiction affect a sizeable
proportion of the human population and severely compromise quality of life. Therefore …

Statins are commonly prescribed medications widely investigated for their potential actions
on the brain and mental health. Pre-clinical and clinical evidence suggests that statins may …

Serotonin type 3 (5-HT3) receptors are pentameric ion channels belonging to the
superfamily of Cys-loop receptors. Receptor activation either leads to fast excitatory …

Mental disorders are highly comorbid and occur together with physical diseases, which are
often considered to arise from separate pathogenic pathways. We observed in alcohol …

Cognitive processes, particularly learning and memory, are crucial brain mechanisms
mediating the successful adaptation of individuals to constantly changing environmental …

Pentameric ligand-gated ion channels (pLGICs) of the Cys-loop receptor family are key
players in fast signal transduction throughout the nervous system. They have been shown to …

Abstract Serotonin (5-hydroxytryptamine, 5-HT) is an intrinsically fluorescent
neurotransmitter found in organisms spanning a wide evolutionary range. Serotonin exerts …