[HTML][HTML] Stem cell-based therapy for human diseases

DM Hoang, PT Pham, TQ Bach, ATL Ngo… - Signal transduction and …, 2022 - nature.com
Recent advancements in stem cell technology open a new door for patients suffering from
diseases and disorders that have yet to be treated. Stem cell-based therapy, including …

The blood–brain barrier and blood–tumour barrier in brain tumours and metastases

CD Arvanitis, GB Ferraro, RK Jain - Nature Reviews Cancer, 2020 - nature.com
For a blood-borne cancer therapeutic agent to be effective, it must cross the blood vessel
wall to reach cancer cells in adequate quantities, and it must overcome the resistance …

Shattering barriers toward clinically meaningful MSC therapies

O Levy, R Kuai, EMJ Siren, D Bhere, Y Milton… - Science …, 2020 - science.org
More than 1050 clinical trials are registered at FDA. gov that explore multipotent
mesenchymal stromal cells (MSCs) for nearly every clinical application imaginable …

Opportunities and challenges of translational 3D bioprinting

SV Murphy, P De Coppi, A Atala - Nature biomedical engineering, 2020 - nature.com
Abstract 3D-printed orthopaedic devices and surgical tools, printed maxillofacial implants
and other printed acellular devices have been used in patients. By contrast, bioprinted living …

Human embryonic stem cell–derived cardiomyocytes restore function in infarcted hearts of non-human primates

YW Liu, B Chen, X Yang, JA Fugate, FA Kalucki… - Nature …, 2018 - nature.com
Pluripotent stem cell–derived cardiomyocyte grafts can remuscularize substantial amounts
of infarcted myocardium and beat in synchrony with the heart, but in some settings cause …

Induced pluripotent stem cell technology: a decade of progress

Y Shi, H Inoue, JC Wu, S Yamanaka - Nature reviews Drug discovery, 2017 - nature.com
Since the advent of induced pluripotent stem cell (iPSC) technology a decade ago,
enormous progress has been made in stem cell biology and regenerative medicine. Human …

Mesenchymal stromal/stem cells in regenerative medicine and tissue engineering

REB Fitzsimmons, MS Mazurek, A Soos… - Stem cells …, 2018 - Wiley Online Library
As a result of over five decades of investigation, mesenchymal stromal/stem cells (MSCs)
have emerged as a versatile and frequently utilized cell source in the fields of regenerative …

Mitochondria as central regulators of neural stem cell fate and cognitive function

M Khacho, R Harris, RS Slack - Nature Reviews Neuroscience, 2019 - nature.com
Emerging evidence now indicates that mitochondria are central regulators of neural stem
cell (NSC) fate decisions and are crucial for both neurodevelopment and adult …

MYCN function in neuroblastoma development

J Otte, C Dyberg, A Pepich, JI Johnsen - Frontiers in oncology, 2021 - frontiersin.org
Dysregulated expression of the transcription factor MYCN is frequently detected in nervous
system tumors such as childhood neuroblastoma. Here, gene amplification of MYCN is a …

Human germ cell tumours from a developmental perspective

JW Oosterhuis, LHJ Looijenga - Nature Reviews Cancer, 2019 - nature.com
Human germ cell tumours (GCTs) are derived from stem cells of the early embryo and the
germ line. They occur in the gonads (ovaries and testes) and also in extragonadal sites …