Background Beta-lactam antibiotics (βLA) are the most commonly used antibiotics in the
intensive care unit (ICU). ICU patients present many pathophysiological features that cause …

Early management of sepsis and septic shock is crucial for patients' prognosis. As the
Emergency Department (ED) is the place where the first medical contact for septic patients is …

Background A growing body of observational evidence supports the value of ceftazidime-
avibactam (CAZ-AVI) in managing infections caused by carbapenem-resistant …

Rationale: Optimization of β-lactam antibiotic dosing for critically ill patients is an intervention
that may improve outcomes in severe sepsis. Objectives: In this individual patient data meta …

Purpose This study aims to determine if continuous infusion (CI) is associated with better
clinical and pharmacokinetic/pharmacodynamic (PK/PD) outcomes compared to intermittent …

Antimicrobials are among the most important and commonly prescribed drugs in the
management of critically ill patients and beta-lactams are the most common antibiotic class …

Brazil nuts are among the richest selenium food sources, and studies have considered this
Amazonian nut as an alternative for selenium supplementation. Besides selenium, Brazil …

Sepsis is a medical emergency and life-threatening condition due to a dysregulated host
response to infection, which is time-dependent and associated with unacceptably high …

Purpose Standard dosing and intermittent bolus application (IB) are important risk factors for
pharmacokinetic (PK) target non-attainment during empirical treatment with β-lactams in …

Background Meropenem exhibits time-dependent antimicrobial activity and prolonged
infusion (PI)(extended infusion or continuous infusion, EI or CI) of meropenem can better …