Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis

W Chen, M Schilperoort, Y Cao, J Shi, I Tabas… - Nature Reviews …, 2022 - nature.com
Nanotechnology could improve our understanding of the pathophysiology of atherosclerosis
and contribute to the development of novel diagnostic and therapeutic strategies to further …

Chemistry of MRI contrast agents: current challenges and new frontiers

J Wahsner, EM Gale, A Rodríguez-Rodríguez… - Chemical …, 2018 - ACS Publications
Tens of millions of contrast-enhanced magnetic resonance imaging (MRI) exams are
performed annually around the world. The contrast agents, which improve diagnostic …

Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications

SM Dadfar, K Roemhild, NI Drude… - Advanced drug delivery …, 2019 - Elsevier
Many different iron oxide nanoparticles have been evaluated over the years, for a wide
variety of biomedical applications. We here summarize the synthesis, surface …

Successful anti-PD-1 cancer immunotherapy requires T cell-dendritic cell crosstalk involving the cytokines IFN-γ and IL-12

CS Garris, SP Arlauckas, RH Kohler, MP Trefny… - Immunity, 2018 - cell.com
Anti-PD-1 immune checkpoint blockers can induce sustained clinical responses in cancer
but how they function in vivo remains incompletely understood. Here, we combined intravital …

TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy

CB Rodell, SP Arlauckas, MF Cuccarese… - Nature biomedical …, 2018 - nature.com
Tumour-associated macrophages are abundant in many cancers, and often display an
immune-suppressive M2-like phenotype that fosters tumour growth and promotes resistance …

DNA nanotechnology-enabled drug delivery systems

Q Hu, H Li, L Wang, H Gu, C Fan - Chemical reviews, 2018 - ACS Publications
Over the past decade, we have seen rapid advances in applying nanotechnology in
biomedical areas including bioimaging, biodetection, and drug delivery. As an emerging …

[HTML][HTML] Manganese ferrite (MnFe2O4) nanostructures for cancer theranostics

CR Kalaiselvan, SS Laha, SB Somvanshi… - Coordination Chemistry …, 2022 - Elsevier
Over the past decade, transition metal-based ferrite nanostructures, displaying MFe 2 O 4
stoichiometry (M 2+ cations, eg, Mn, Co, Ni and Zn), have been devised and examined …

Nanomaterials for in vivo imaging

BR Smith, SS Gambhir - Chemical reviews, 2017 - ACS Publications
In vivo imaging, which enables us to peer deeply within living subjects, is producing
tremendous opportunities both for clinical diagnostics and as a research tool. Contrast …

Iron oxide nanoparticles inhibit tumour growth by inducing pro-inflammatory macrophage polarization in tumour tissues

S Zanganeh, G Hutter, R Spitler, O Lenkov… - Nature …, 2016 - nature.com
Until now, the Food and Drug Administration (FDA)-approved iron supplement ferumoxytol
and other iron oxide nanoparticles have been used for treating iron deficiency, as contrast …

Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles

AP Singh, A Biswas, A Shukla, P Maiti - Signal transduction and …, 2019 - nature.com
The application of nanomedicines is increasing rapidly with the promise of targeted and
efficient drug delivery. Nanomedicines address the shortcomings of conventional therapy, as …