Ten things you should know about transposable elements

G Bourque, KH Burns, M Gehring, V Gorbunova… - Genome biology, 2018 - Springer
Transposable elements (TEs) are major components of eukaryotic genomes. However, the
extent of their impact on genome evolution, function, and disease remain a matter of intense …

The impact of retrotransposons on human genome evolution

R Cordaux, MA Batzer - Nature reviews genetics, 2009 - nature.com
Their ability to move within genomes gives transposable elements an intrinsic propensity to
affect genome evolution. Non-long terminal repeat (LTR) retrotransposons—including LINE …

Copy number variation in human health, disease, and evolution

F Zhang, W Gu, ME Hurles… - Annual review of …, 2009 - annualreviews.org
Copy number variation (CNV) is a source of genetic diversity in humans. Numerous CNVs
are being identified with various genome analysis platforms, including array comparative …

Active human retrotransposons: variation and disease

DC Hancks, HH Kazazian Jr - Current opinion in genetics & development, 2012 - Elsevier
Mobile DNAs, also known as transposons or 'jum** genes', are widespread in nature and
comprise an estimated 45% of the human genome. Transposons are divided into two …

[BOOK][B] Human evolutionary genetics: origins, peoples and disease

M Jobling, C Tyler-Smith - 2019 - taylorfrancis.com
Human Evolutionary Genetics is a groundbreaking text which for the first time brings
together molecular genetics and genomics to the study of the origins and movements of …

LINE-1 elements in structural variation and disease

CR Beck, JL Garcia-Perez, RM Badge… - Annual review of …, 2011 - annualreviews.org
The completion of the human genome reference sequence ushered in a new era for the
study and discovery of human transposable elements. It now is undeniable that …

Coevolution between transposable elements and recombination

TV Kent, J Uzunović, SI Wright - … Transactions of the …, 2017 - royalsocietypublishing.org
One of the most striking patterns of genome structure is the tight, typically negative,
association between transposable elements (TEs) and meiotic recombination rates. While …

Transposable elements: genome innovation, chromosome diversity, and centromere conflict

SJ Klein, RJ O'Neill - Chromosome Research, 2018 - Springer
Although it was nearly 70 years ago when transposable elements (TEs) were first
discovered “jum**” from one genomic location to another, TEs are now recognized as …

The impact of transposable elements on eukaryotic genomes: from genome size increase to genetic adaptation to stressful environments

B Chénais, A Caruso, S Hiard, N Casse - Gene, 2012 - Elsevier
Transposable elements (TEs) are present in roughly all genomes. These mobile DNA
sequences are able to invade genomes and their impact on genome evolution is substantial …

The landscape of L1 retrotransposons in the human genome is shaped by pre-insertion sequence biases and post-insertion selection

T Sultana, D van Essen, O Siol, M Bailly-Bechet… - Molecular cell, 2019 - cell.com
L1 retrotransposons are transposable elements and major contributors of genetic variation
in humans. Where L1 integrates into the genome can directly impact human evolution and …