We have previously described a new series of selective and orally available galectin-1
inhibitors resulting in the thiazole-containing glycomimetic GB1490. Here, we show that the …

A new series of orally available α-d-galactopyranosides with high affinity and specificity
toward galectin-1 have been discovered. High affinity and specificity were achieved by …

Galectin-1 (Gal-1), a 14kDa carbohydrate-binding protein of the galectin family found in
humans, affects intracellular signaling pathways upon interaction with β-galactosides on cell …

Novel cationic glycoliposomes, composed of 1, 2-dioleoyl-sn-glycero-3-phosphocholine
(DOPC), cholesterol (Chol) and glycoamphiphiles featuring a galactosyl, mannosyl or …

Galectins are β-galactosyl-binding proteins that fulfill essential physiological functions. In the
biotechnological field, galectins are versatile tools, such as in the development of …

The study of mechanism of action of Thymosin alpha 1 (Tα1) and the basis of the pleiotropic
effect in health and disease, is one of the main focus of our ongoing research. Tα1 is a …

Galectins are a family of beta-galactoside-binding proteins that are characterised by their
carbohydrate recognition domain (CRD) and include galectin-1 and galectin-3. These …

Abstract Introduction: Galectin-1 (Gal-1) is a lectin that has been shown to be involved in a
number of pro-tumorigenic mechanisms and has also been shown to be immune …

Hypersialylation is a prognostic biomarker in cancer cells. The upregulated sialic acid
expression on cancer cells facilitates tumorigenesis by playing a critical role in cancer cell …

Galectins are a family of lectins characterized by their carbohydrate recognition domains
containing eight conserved amino acid residues, which allows the binding of galectin to β …