Similarities and differences in the associations of biological entities among species can
provide us with a better understanding of evolutionary relationships. Often the evolution of …

Systems biology is an inclusive approach to study the static and dynamic emergent
properties on a global scale by integrating multiomics datasets to establish qualitative and …

In the last two decades, advances in network science have facilitated the discovery of
important systems' entities in diverse biological networks. This graph-based technique has …

Dissecting the relationship between gene function and substitution rates is key to
understanding genome-wide patterns of molecular evolution. Biochemical pathways provide …

The Populus genus is one of the major plant model systems, but genomic resources have
thus far primarily been available for poplar species, and primarily Populus trichocarpa (Torr …

Background Mouse models have allowed for the direct interrogation of genetic effects on
molecular, physiological, and behavioral brain phenotypes. However, it is unknown to what …

Highly pleiotropic genes are predicted to be used less often during adaptation, as mutations
in these loci are more likely to have negative fitness consequences. Following this logic, we …

Gene co-expression analysis is a data analysis technique that helps identify groups of
genes with similar expression patterns across several different conditions. By means of …

Pleiotropy, the control of multiple phenotypes by a single locus, is expected to slow the rate
of adaptation by increasing the chance that beneficial alleles also have deleterious effects …

Background Individual organisms may exhibit phenotypic plasticity when they acclimate to
different conditions. Such plastic responses may facilitate or constrain the adaptation of their …