The BCR-ABL1 oncoprotein transforms pluripotent HSCs and initiates chronic myeloid
leukemia (CML). Patients with early phase (also known as chronic phase [CP]) disease …

In recent years, great progress has been made in elucidating the progenitor-cell hierarchy of
the myeloid lineage. Transcription factors have been shown to be key determinants in the …

The C/EBP family of proteins represents an important group of bZIP transcription factors that
are key to the regulation of essential functions such as cell cycle, hematopoiesis, skeletal …

During'emergency'situations such as infections, host defense requires rapid mobilization of
bone marrow granulocyte progenitors.'Steady-state'granulopoiesis is absolutely dependent …

PU. 1 directs the hematopoietic stem cell to the lymphoid-myeloid progenitor (LMP) and
interacts with GATA-binding protein 1 to inhibit commitment to the megakaryocyte-erythroid …

A characteristic feature of leukemia cells is a blockade of differentiation at a distinct stage in
cellular maturation. In the 1970s and 1980s, studies demonstrating the capabilities of certain …

Review of the intracellular pathway of TREM-1 signaling, its interactions with PRR pathways,
focusing on TLRs and NLRs. TREM-1 is an important signaling receptor expressed on …

At the cellular level, the biological processes of cell proliferation, growth arrest,
differentiation and apoptosis are all tightly coupled to appropriate alterations in metabolic …

Relevance of mitogen-activated protein kinases ERK, JNK, and p38 in the regulation of
myeloid differentiation. The MAPKs are a family of serine/threonine kinases that play an …

The CCAAT/enhancer-binding protein (C/EBP) family of transcription factors plays an
important role in controlling cell proliferation and differentiation. C/EBPα is a particularly …