[HTML][HTML] Addressing the challenges of pancreatic cancer: future directions for improving outcomes
Pancreatic ductal adenocarcinoma (PDAC), which accounts for more than 90% of all
pancreatic tumours, is a devastating malignancy with an extremely poor prognosis, as …
pancreatic tumours, is a devastating malignancy with an extremely poor prognosis, as …
Desmoplasia and chemoresistance in pancreatic cancer
M Schober, R Jesenofsky, R Faissner, C Weidenauer… - Cancers, 2014 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) occurs mainly in people older than 50 years of
age. Although great strides have been taken in treating PDAC over the past decades its …
age. Although great strides have been taken in treating PDAC over the past decades its …
Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation
E Fokas, R Prevo, JR Pollard, PM Reaper… - Cell death & …, 2012 - nature.com
Combined radiochemotherapy is the currently used therapy for locally advanced pancreatic
ductal adenocarcinoma (PDAC), but normal tissue toxicity limits its application. Here we test …
ductal adenocarcinoma (PDAC), but normal tissue toxicity limits its application. Here we test …
Completion of adjuvant chemotherapy after upfront surgical resection for pancreatic cancer is uncommon yet associated with improved survival
Background Multiple trials have demonstrated a survival benefit for adjuvant chemotherapy
after resection of pancreatic adenocarcinoma. This study aimed to identify the rate for …
after resection of pancreatic adenocarcinoma. This study aimed to identify the rate for …
[HTML][HTML] Management of pancreatic cancer in the elderly
O Higuera, I Ghanem, R Nasimi, I Prieto… - World journal of …, 2016 - ncbi.nlm.nih.gov
Currently, pancreatic adenocarcinoma mainly occurs after 60 years of age, and its prognosis
remains poor despite modest improvements in recent decades. The aging of the population …
remains poor despite modest improvements in recent decades. The aging of the population …
Orthotopic and heterotopic murine models of pancreatic cancer and their different responses to FOLFIRINOX chemotherapy
Syngeneic, immunocompetent allograft tumor models recapitulate important aspects of the
tumor microenvironment and have short tumor latency with predictable growth kinetics …
tumor microenvironment and have short tumor latency with predictable growth kinetics …
[HTML][HTML] Therapeutic options for the management of pancreatic cancer
ML Rossi, AA Rehman, CS Gondi - World Journal of …, 2014 - ncbi.nlm.nih.gov
Since its initial characterization, pancreatic ductal adenocarcinoma has remained one of the
most devastating and difficult cancers to treat. Pancreatic cancer is the fourth leading cause …
most devastating and difficult cancers to treat. Pancreatic cancer is the fourth leading cause …
Downstaging in stage IV pancreatic cancer: a new population eligible for surgery?
I Frigerio, P Regi, A Giardino, F Scopelliti… - Annals of Surgical …, 2017 - Springer
Background Recent papers consider surgery as an option for synchronous liver
oligometastatic patients [metastatic pancreatic ductal adenocarcinoma (mPDAC)]. In this …
oligometastatic patients [metastatic pancreatic ductal adenocarcinoma (mPDAC)]. In this …
Surgery for pancreatic cancer: current controversies and challenges
Two areas that remain the focus of improvement in pancreatic cancer include high post-
operative morbidity and inability to uniformly translate surgical success into long-term …
operative morbidity and inability to uniformly translate surgical success into long-term …
Neoadjuvant therapy for resectable pancreatic cancer: an evolving paradigm shift
A Chawla, CR Ferrone - Frontiers in Oncology, 2019 - frontiersin.org
Non-metastatic pancreatic adenocarcinoma (PDAC) is associated with a high rate of
recurrence and lethality. In addition, less than half of all patients are able to complete …
recurrence and lethality. In addition, less than half of all patients are able to complete …