[HTML][HTML] Addressing the challenges of pancreatic cancer: future directions for improving outcomes

M Hidalgo, S Cascinu, J Kleeff, R Labianca, JM Löhr… - Pancreatology, 2015 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC), which accounts for more than 90% of all
pancreatic tumours, is a devastating malignancy with an extremely poor prognosis, as …

Desmoplasia and chemoresistance in pancreatic cancer

M Schober, R Jesenofsky, R Faissner, C Weidenauer… - Cancers, 2014 - mdpi.com
Pancreatic ductal adenocarcinoma (PDAC) occurs mainly in people older than 50 years of
age. Although great strides have been taken in treating PDAC over the past decades its …

Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation

E Fokas, R Prevo, JR Pollard, PM Reaper… - Cell death & …, 2012 - nature.com
Combined radiochemotherapy is the currently used therapy for locally advanced pancreatic
ductal adenocarcinoma (PDAC), but normal tissue toxicity limits its application. Here we test …

Completion of adjuvant chemotherapy after upfront surgical resection for pancreatic cancer is uncommon yet associated with improved survival

AM Altman, K Wirth, S Marmor, E Lou, K Chang… - Annals of surgical …, 2019 - Springer
Background Multiple trials have demonstrated a survival benefit for adjuvant chemotherapy
after resection of pancreatic adenocarcinoma. This study aimed to identify the rate for …

[HTML][HTML] Management of pancreatic cancer in the elderly

O Higuera, I Ghanem, R Nasimi, I Prieto… - World journal of …, 2016 - ncbi.nlm.nih.gov
Currently, pancreatic adenocarcinoma mainly occurs after 60 years of age, and its prognosis
remains poor despite modest improvements in recent decades. The aging of the population …

Orthotopic and heterotopic murine models of pancreatic cancer and their different responses to FOLFIRINOX chemotherapy

DJ Erstad, M Sojoodi, MS Taylor… - Disease models & …, 2018 - journals.biologists.com
Syngeneic, immunocompetent allograft tumor models recapitulate important aspects of the
tumor microenvironment and have short tumor latency with predictable growth kinetics …

[HTML][HTML] Therapeutic options for the management of pancreatic cancer

ML Rossi, AA Rehman, CS Gondi - World Journal of …, 2014 - ncbi.nlm.nih.gov
Since its initial characterization, pancreatic ductal adenocarcinoma has remained one of the
most devastating and difficult cancers to treat. Pancreatic cancer is the fourth leading cause …

Downstaging in stage IV pancreatic cancer: a new population eligible for surgery?

I Frigerio, P Regi, A Giardino, F Scopelliti… - Annals of Surgical …, 2017 - Springer
Background Recent papers consider surgery as an option for synchronous liver
oligometastatic patients [metastatic pancreatic ductal adenocarcinoma (mPDAC)]. In this …

Surgery for pancreatic cancer: current controversies and challenges

M Karunakaran, SG Barreto - Future Oncology, 2021 - Taylor & Francis
Two areas that remain the focus of improvement in pancreatic cancer include high post-
operative morbidity and inability to uniformly translate surgical success into long-term …

Neoadjuvant therapy for resectable pancreatic cancer: an evolving paradigm shift

A Chawla, CR Ferrone - Frontiers in Oncology, 2019 - frontiersin.org
Non-metastatic pancreatic adenocarcinoma (PDAC) is associated with a high rate of
recurrence and lethality. In addition, less than half of all patients are able to complete …