Immune-checkpoint inhibition provides an unmatched level of durable clinical efficacy in
various malignancies. Such therapies promote the activation of antigen-specific T cells …

The immunopeptidome is the set of peptides presented by the major histocompatibility
complex (MHC) molecules, in humans also known as the human leukocyte antigen (HLA) …

Peptide antigens bound to molecules encoded by the major histocompatibility complex
(MHC) and presented on the cell surface form the targets of T lymphocytes. This critical arm …

Although mutations may represent attractive targets for immunotherapy, direct identification
of mutated peptide ligands isolated from human leucocyte antigens (HLA) on the surface of …

Protein phosphorylation is a post-translational modification (PTM) that orchestrates a diverse
array of cellular processes. Because this modification serves as a rapid and reversible …

Definitive experimental evidence from mouse cancer models and strong correlative clinical
data gave rise to the Cancer Immunoediting concept that explains the dual host-protective …

Metals are essential components in life processes and participate in many important
biological processes. Dysregulation of metal homeostasis is correlated with many diseases …

(MS) and MS-driven proteomics have continued to develop as the premier tools for
characterizing proteome composition, structure, and function. 2 The new era of proteomics …

Highlights•Immunopeptidomics analysis reveals the in vivo antigenic repertoire of
tumors.•Shared cancer antigens and private neo-epitopes are detected by …

The biological compositions including cells, proteins/peptides, nucleic acids, extracellular
vesicles (EVs) and metabolites are no doubt closely related to almost all physiological and …