Transcriptome studies reveal pervasive transcription of complex genomes, such as those of
mammals. Despite popular arguments for functionality of most, if not all, of these transcripts …

Our recent ability to sequence entire genomes, along with all of their transcribed RNAs, has
led to the surprising finding that only∼ 1% of the human genome is used to encode proteins …

The early window of human embryogenesis is largely a black box for developmental
biologists. Here we probed the cellular diversity of 4–6 week human embryos when …

Hox genes play key roles in axial patterning and regulating the regional identity of cells and
tissues in a wide variety of animals from invertebrates to vertebrates. Nested domains of Hox …

One of the major regulatory challenges of animal development is to precisely coordinate in
space and time the formation, specification, and patterning of cells that underlie elaboration …

Animal body plans are established during embryonic development by the Hox genes. This
patterning process relies on the differential expression of Hox genes along the head-to-tail …

The coordinated expression of the Hox gene family encoding transcription factors is critical
for proper embryonic development and patterning. Major efforts have thus been dedicated to …

Objective Long intergenic non-coding RNAs (lincRNAs) are emerging as key regulators in
gene expression; however, little is known about the lincRNA expression changes that occur …

Animals rely on genomic regulatory systems to direct the dynamic spatiotemporal and cell-
type specific gene expression that is essential for the development and maintenance of a …

The early window of human embryogenesis is largely a black box for developmental
biologists. Here we probed the cellular diversity of 4-to 6-week human embryos when …