Mitochondrial dysfunctions, oxidative stress and neuroinflammation as therapeutic targets for neurodegenerative diseases: An update on current advances and …

MU Rehman, N Sehar, NJ Dar, A Khan, A Arafah… - Neuroscience & …, 2023 - Elsevier
Neurodegenerative diseases (NDs) such as Alzheimer disease (AD), Parkinson disease
(PD), and Huntington disease (HD) represent a major socio-economic challenge in view of …

Targeting pyroptosis as a preventive and therapeutic approach for stroke

J Long, Y Sun, S Liu, S Yang, C Chen, Z Zhang… - Cell death …, 2023 - nature.com
Stroke has caused tremendous social stress worldwide, yet despite decades of research
and development of new stroke drugs, most have failed and rt-PA (Recombinant tissue …

The mitochondrial permeability transition pore—current knowledge of its structure, function, and regulation, and optimized methods for evaluating its functional state

R Endlicher, Z Drahota, K Štefková, Z Červinková… - Cells, 2023 - mdpi.com
The mitochondrial permeability transition pore (MPTP) is a calcium-dependent, ion non-
selective membrane pore with a wide range of functions. Although the MPTP has been …

Role of pyroptosis in the pathogenesis of various neurological diseases

A Oladapo, T Jackson, J Menolascino… - Brain, Behavior, and …, 2024 - Elsevier
Pyroptosis, an inflammatory programmed cell death process, has recently garnered
significant attention due to its pivotal role in various neurological diseases. This review …

Mitochondria dysfunction and neuroinflammation in neurodegeneration: who comes first?

C Peggion, T Calì, M Brini - Antioxidants, 2024 - mdpi.com
Neurodegenerative diseases (NDs) encompass an assorted array of disorders such as
Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, each …

Emerging evidence for astrocyte dysfunction in schizophrenia

EC de Oliveira Figueiredo, C Calì, F Petrelli, P Bezzi - Glia, 2022 - Wiley Online Library
Schizophrenia is a complex, chronic mental health disorder whose heterogeneous genetic
and neurobiological background influences early brain development, and whose precise …

Modulating nitric oxide: implications for cytotoxicity and cytoprotection

I Belenichev, O Popazova, N Bukhtiyarova… - Antioxidants, 2024 - mdpi.com
Despite the significant progress in the fields of biology, physiology, molecular medicine, and
pharmacology; the designation of the properties of nitrogen monoxide in the regulation of life …

Mitochondrial permeability transition, cell death and neurodegeneration

AY Baev, AY Vinokurov, EV Potapova, AV Dunaev… - Cells, 2024 - mdpi.com
Neurodegenerative diseases are chronic conditions occurring when neurons die in specific
brain regions that lead to loss of movement or cognitive functions. Despite the progress in …

Insights into the molecular mechanisms of NRF2 in kidney injury and diseases

DW Lin, YC Hsu, CC Chang, CC Hsieh… - International Journal of …, 2023 - mdpi.com
Redox is a constant phenomenon in organisms. From the signaling pathway transduction to
the oxidative stress during the inflammation and disease process, all are related to reduction …

SOD1 in ALS: taking stock in pathogenic mechanisms and the role of glial and muscle cells

C Peggion, V Scalcon, ML Massimino, K Nies… - Antioxidants, 2022 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by
the loss of motor neurons in the brain and spinal cord. While the exact causes of ALS are still …