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Mitochondrial dysfunctions, oxidative stress and neuroinflammation as therapeutic targets for neurodegenerative diseases: An update on current advances and …
Neurodegenerative diseases (NDs) such as Alzheimer disease (AD), Parkinson disease
(PD), and Huntington disease (HD) represent a major socio-economic challenge in view of …
(PD), and Huntington disease (HD) represent a major socio-economic challenge in view of …
Targeting pyroptosis as a preventive and therapeutic approach for stroke
J Long, Y Sun, S Liu, S Yang, C Chen, Z Zhang… - Cell death …, 2023 - nature.com
Stroke has caused tremendous social stress worldwide, yet despite decades of research
and development of new stroke drugs, most have failed and rt-PA (Recombinant tissue …
and development of new stroke drugs, most have failed and rt-PA (Recombinant tissue …
The mitochondrial permeability transition pore—current knowledge of its structure, function, and regulation, and optimized methods for evaluating its functional state
R Endlicher, Z Drahota, K Štefková, Z Červinková… - Cells, 2023 - mdpi.com
The mitochondrial permeability transition pore (MPTP) is a calcium-dependent, ion non-
selective membrane pore with a wide range of functions. Although the MPTP has been …
selective membrane pore with a wide range of functions. Although the MPTP has been …
Role of pyroptosis in the pathogenesis of various neurological diseases
A Oladapo, T Jackson, J Menolascino… - Brain, Behavior, and …, 2024 - Elsevier
Pyroptosis, an inflammatory programmed cell death process, has recently garnered
significant attention due to its pivotal role in various neurological diseases. This review …
significant attention due to its pivotal role in various neurological diseases. This review …
Mitochondria dysfunction and neuroinflammation in neurodegeneration: who comes first?
Neurodegenerative diseases (NDs) encompass an assorted array of disorders such as
Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, each …
Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, each …
Emerging evidence for astrocyte dysfunction in schizophrenia
Schizophrenia is a complex, chronic mental health disorder whose heterogeneous genetic
and neurobiological background influences early brain development, and whose precise …
and neurobiological background influences early brain development, and whose precise …
Modulating nitric oxide: implications for cytotoxicity and cytoprotection
Despite the significant progress in the fields of biology, physiology, molecular medicine, and
pharmacology; the designation of the properties of nitrogen monoxide in the regulation of life …
pharmacology; the designation of the properties of nitrogen monoxide in the regulation of life …
Mitochondrial permeability transition, cell death and neurodegeneration
Neurodegenerative diseases are chronic conditions occurring when neurons die in specific
brain regions that lead to loss of movement or cognitive functions. Despite the progress in …
brain regions that lead to loss of movement or cognitive functions. Despite the progress in …
Insights into the molecular mechanisms of NRF2 in kidney injury and diseases
DW Lin, YC Hsu, CC Chang, CC Hsieh… - International Journal of …, 2023 - mdpi.com
Redox is a constant phenomenon in organisms. From the signaling pathway transduction to
the oxidative stress during the inflammation and disease process, all are related to reduction …
the oxidative stress during the inflammation and disease process, all are related to reduction …
SOD1 in ALS: taking stock in pathogenic mechanisms and the role of glial and muscle cells
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by
the loss of motor neurons in the brain and spinal cord. While the exact causes of ALS are still …
the loss of motor neurons in the brain and spinal cord. While the exact causes of ALS are still …