Brain tissue responses to neural implants impact signal sensitivity and intervention strategies

TDY Kozai, AS Jaquins-Gerstl… - ACS chemical …, 2015 - ACS Publications
Implantable biosensors are valuable scientific tools for basic neuroscience research and
clinical applications. Neurotechnologies provide direct readouts of neurological signal and …

Neurotrophin signalling: novel insights into mechanisms and pathophysiology

M Mitre, A Mariga, MV Chao - Clinical science, 2017 - portlandpress.com
Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are prominent regulators
of neuronal survival, growth and differentiation during development. While trophic factors are …

[HTML][HTML] Celebrating the one millionth cochlear implant

FG Zeng - JASA Express Letters, 2022 - pubs.aip.org
Cochlear implants have been the most successful neural prosthesis, with one million users
globally. Researchers used the source-filter model and speech vocoder to design the …

Minimally invasive power sources for implantable electronics

M Xu, Y Liu, K Yang, S Li, M Wang, J Wang… - …, 2024 - Wiley Online Library
As implantable medical electronics (IMEs) developed for healthcare monitoring and
biomedical therapy are extensively explored and deployed clinically, the demand for non …

Non-viral gene therapy: Gains and challenges of non-invasive administration methods

M Foldvari, DW Chen, N Nafissi, D Calderon… - Journal of Controlled …, 2016 - Elsevier
Gene therapy is becoming an influential part of the rapidly increasing armamentarium of
biopharmaceuticals for improving health and combating diseases. Currently, three gene …

Implantable electrical stimulation at dorsal root ganglions accelerates osteoporotic fracture healing via calcitonin gene‐related peptide

J Mi, JK Xu, Z Yao, H Yao, Y Li, X He, BY Dai… - Advanced …, 2022 - Wiley Online Library
The neuronal engagement of the peripheral nerve system plays a crucial role in regulating
fracture healing, but how to modulate the neuronal activity to enhance fracture healing …

How we hear: The perception and neural coding of sound

AJ Oxenham - Annual review of psychology, 2018 - annualreviews.org
Auditory perception is our main gateway to communication with others via speech and
music, and it also plays an important role in alerting and orienting us to new events. This …

[HTML][HTML] Inner ear gene therapies take off: current promises and future challenges

S Delmaghani, A El-Amraoui - Journal of clinical medicine, 2020 - mdpi.com
Hearing impairment is the most frequent sensory deficit in humans of all age groups, from
children (1/500) to the elderly (more than 50% of the over-75 s). Over 50% of congenital …

Development of neural interfaces and energy harvesters towards self-powered implantable systems for healthcare monitoring and rehabilitation purposes

J Wang, T He, C Lee - Nano Energy, 2019 - Elsevier
Despite its great promise, neural interface has yet to substantially impact modern healthcare
monitoring and therapeutic interventions. However, considering the recent development of …

Toward optogenetic hearing restoration

A Huet, T Mager, C Gossler… - Annual Review of …, 2024 - annualreviews.org
The cochlear implant (CI) is considered the most successful neuroprosthesis as it enables
speech comprehension in the majority of the million otherwise deaf patients. In hearing by …