Myelin is a modified cell membrane that forms a multilayer sheath around the axon. It retains
the main characteristics of biological membranes, such as lipid bilayer, but differs from them …

Oligodendrocyte progenitor cells (OPCs) play pivotal roles in myelin formation and
phagocytosis, communicating with neighboring cells and contributing to the integrity of the …

Multiple sclerosis (MS) pathophysiology includes inflammation, demyelination and
neurodegeneration, but the exact mechanisms of disease initiation and progression are …

Myelin water fraction (MWF) imaging has emerged as a promising magnetic resonance
imaging (MRI) biomarker for investigating brain function and composition. This …

Objectives To quantify brain microstructural changes in recently diagnosed relapsing-
remitting multiple sclerosis (RRMS) using longitudinal T 1 measures, and determine their …

Introduction Quantitative microstructural MRI, such as myelin-sensitive magnetisation
transfer ratio (MTR) or saturation (MTsat), axon-sensitive water diffusion Neurite Orientation …

O‐sulfogalactosylceramide (sulfatide) constitutes a class of sphingolipids that comprise
about 4% of myelin lipids in the central nervous system. Previously, our group characterized …

Electron microscopy (EM) images of axons and their ensheathing myelin from both the
central and peripheral nervous system are used for assessing myelin formation …

The myelin concentration and the degree of myelination of nerve fibers can provide valuable
information on the integrity of human brain tissue. Magnetic resonance imaging (MRI) of …

Introduction: Multiple sclerosis (MS) is a chronic neuroinflammatory and neurodegenerative
disease. MS prevalence varies geographically and is notably high in Scotland. Disease …