Dysregulated RNA splicing is a molecular feature that characterizes almost all tumour types.
Cancer-associated splicing alterations arise from both recurrent mutations and altered …

Somatic mutations in genes encoding components of the RNA splicing machinery occur
frequently in multiple forms of cancer. The most frequently mutated RNA splicing factors in …

Transcription and splicing of pre-messenger RNA are closely coordinated, but how this
functional coupling is disrupted in human diseases remains unexplored. Using isogenic cell …

Precursor messenger RNA (pre-mRNA) splicing is catalyzed by an intricate
ribonucleoprotein complex called the spliceosome. Although the spliceosome is considered …

ATP-dependent chromatin remodeling SWI/SNF complexes exist in three subcomplexes:
canonical BAF (cBAF), polybromo BAF (PBAF), and a newly described non-canonical BAF …

High-throughput sequencing and functional characterization of the cancer transcriptome
have uncovered cancer-specific dysregulation of RNA splicing across a variety of cancers …

RNA splicing factor SF3B1 is recurrently mutated in various cancers, particularly in
hematologic malignancies. We previously reported that coexpression of Sf3b1 mutation and …

The question of how same-gene mutations can drive both cancer and neurodevelopmental
disorders has been puzzling. It has also been puzzling why those with neurodevelopmental …

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive leukemia of
plasmacytoid dendritic cells (pDC). BPDCN occurs at least three times more frequently in …

Despite the identification of driver mutations leading to the initiation of myeloproliferative
neoplasms (MPNs), the molecular pathogenesis of MPNs remains incompletely understood …