Molecular mechanisms of environmental pollutant-induced cartilage damage: from developmental disorders to osteoarthritis

AV Skalny, M Aschner, F Zhang, X Guo… - Archives of …, 2024 - Springer
The objective of the present study was to review the molecular mechanisms of the adverse
effects of environmental pollutants on chondrocytes and extracellular matrix (ECM). Existing …

[HTML][HTML] The role of blood vessels in broiler chickens with tibial dyschondroplasia

S Huang, A Kong, Q Cao, Z Tong, X Wang - Poultry science, 2019 - Elsevier
Tibial dyschondroplasia (TD) is an intractable tibiotarsal bone disorder of rapid growing
avian species, which leads to huge economic losses and compromised poultry welfare …

A ratiometric fluorescent sensing system for the selective and ultrasensitive detection of pesticide residues via the synergetic effects of copper nanoclusters and …

L Chen, J Lu, M Luo, H Yu, X Chen, J Deng, X Hou… - Food Chemistry, 2022 - Elsevier
Agricultural products, such as foodstuffs and herbal medicines, may be contaminated by
pesticides. Therefore, develo** sensitive methods for pesticide detection are urgently …

Thiram-induced hyperglycemia causes tibial dyschondroplasia by triggering aberrant ECM remodeling via the gut-pancreas axis in broiler chickens

Q Mo, MFA Kulyar, C Quan, Y Ding, Y Zhang… - Journal of Hazardous …, 2023 - Elsevier
Pesticide thiram is widely used in agriculture and has been demonstrated to cause tibial
dyschondroplasia (TD) in birds. However, the underlying mechanism remains unclear. This …

Molecular mechanism of miR-203a targeting Runx2 to regulate thiram induced-chondrocyte development

S Wu, K Liu, X Huang, Q Sun, X Wu, K Mehmood… - Pesticide Biochemistry …, 2024 - Elsevier
Thiram is a kind of organic compound, which is commonly used for sterilization, insecticidal
and deodorization in daily life. Its toxicology has been broadly studied. Recently, more and …

The autophagy-mediated mechanism via TSC1/mTOR signaling pathway in thiram-induced tibial dyschondroplasia of broilers

C Quan, S Zhou, Y Zhang, MFA Kulyar, S Gong… - Science of The Total …, 2024 - Elsevier
Thiram is a member of the dithiocarbamate family and is widely used in agriculture,
especially in low-income countries. Its residues lead to various diseases, among which tibial …

Role of oxidative stress and antioxidants in thiram-induced tibial dyschondroplasia

B Liu, Y Li, K Mehmood, F Nabi, S Ahmed, T Rehman… - 2021 - digital.csic.es
Tetramethyl thiuram disulfide (thiram) is an important dithiocarbamate bactericide; it has
been widely used for the control of various diseases in fruits, vegetables, seeds and food …

Puerarin enhance vascular proliferation and halt apoptosis in thiram-induced avian tibial dyschondroplasia by regulating HIF-1α, TIMP-3 and BCL-2 expressions

M Waqas, H Qamar, J Zhang, W Yao, A Li… - Ecotoxicology and …, 2020 - Elsevier
Tetramethyl thiuram disulfide (thiram) is a dithiocarbamate pesticide used for crop protection
and storage. But, it's widespread utilization is associated with deleterious growth plate …

Thiram-induced cytotoxicity and oxidative stress in human erythrocytes: an in vitro study

S Salam, A Arif, R Mahmood - Pesticide biochemistry and physiology, 2020 - Elsevier
Tetramethylthiuram disulfide, commonly known as thiram, is an organosulfur compound
which is used as a bactericide, fungicide and ectoparasiticide to prevent disease in seeds …

[HTML][HTML] Comprehensive analysis of differently expression mRNA and non-coding RNAs, and their regulatory mechanisms on relationship in thiram-induced tibial …

Y Lu, H Xu, Y Jiang, Z Hu, R Du, X Zhao, Y Tian… - Ecotoxicology and …, 2022 - Elsevier
Thiram pollution is one of the main causes of tibial dyschondroplasia (TD) induced by feed
sources. Several studies have speculated that miRNA, circRNA and lncRNA may have …