Seed amplification assay for the detection of pathologic alpha-synuclein aggregates in cerebrospinal fluid
Misfolded alpha-synuclein (αSyn) aggregates are a hallmark event in Parkinson's disease
(PD) and other synucleinopathies. Recently, αSyn seed amplification assays (αSyn-SAAs) …
(PD) and other synucleinopathies. Recently, αSyn seed amplification assays (αSyn-SAAs) …
Prions, prionoids and protein misfolding disorders
Prion diseases are progressive, incurable and fatal neurodegenerative conditions. The term
'prion'was first nominated to express the revolutionary concept that a protein could be …
'prion'was first nominated to express the revolutionary concept that a protein could be …
Development of a biochemical diagnosis of Parkinson disease by detection of α-synuclein misfolded aggregates in cerebrospinal fluid
Importance Parkinson disease (PD) is a highly prevalent and incurable neurodegenerative
disease associated with the accumulation of misfolded α-synuclein (αSyn) aggregates. An …
disease associated with the accumulation of misfolded α-synuclein (αSyn) aggregates. An …
Transfusion-related mortality: the ongoing risks of allogeneic blood transfusion and the available strategies for their prevention
EC Vamvakas, MA Blajchman - Blood, The Journal of the …, 2009 - ashpublications.org
As the risks of allogeneic blood transfusion (ABT)–transmitted viruses were reduced to
exceedingly low levels in the US, transfusion-related acute lung injury (TRALI), hemolytic …
exceedingly low levels in the US, transfusion-related acute lung injury (TRALI), hemolytic …
Prions: protein aggregation and infectious diseases
A Aguzzi, AM Calella - Physiological reviews, 2009 - journals.physiology.org
Transmissible spongiform encephalopathies (TSEs) are inevitably lethal neurodegenerative
diseases that affect humans and a large variety of animals. The infectious agent responsible …
diseases that affect humans and a large variety of animals. The infectious agent responsible …
Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays
A major problem for the effective diagnosis and management of prion diseases is the lack of
rapid high-throughput assays to measure low levels of prions. Such measurements have …
rapid high-throughput assays to measure low levels of prions. Such measurements have …
Gold nanorods 3D-supercrystals as surface enhanced Raman scattering spectroscopy substrates for the rapid detection of scrambled prions
RA Alvarez-Puebla, A Agarwal… - Proceedings of the …, 2011 - National Acad Sciences
Highly organized supercrystals of Au nanorods with plasmonic antennae enhancement of
electrical field have made possible fast direct detection of prions in complex biological …
electrical field have made possible fast direct detection of prions in complex biological …
Real time quaking‐induced conversion analysis of cerebrospinal fluid in sporadic Creutzfeldt–Jakob disease
LI McGuire, AH Peden, CD Orrú, JM Wilham… - Annals of …, 2012 - Wiley Online Library
Objective: Current cerebrospinal fluid (CSF) tests for sporadic Creutzfeldt–Jakob disease
(sCJD) are based on the detection of surrogate markers of neuronal damage such as CSF …
(sCJD) are based on the detection of surrogate markers of neuronal damage such as CSF …
The prion's elusive reason for being
The protein-only hypothesis posits that the infectious agent causing transmissible
spongiform encephalopathies consists of protein and lacks any informational nucleic acids …
spongiform encephalopathies consists of protein and lacks any informational nucleic acids …
Detection of prions in the plasma of presymptomatic and symptomatic patients with variant Creutzfeldt-Jakob disease
D Bougard, JP Brandel, M Bélondrade… - Science translational …, 2016 - science.org
Variant Creutzfeldt-Jakob disease (vCJD) is a human prion disease resulting from the
consumption of meat products contaminated by the agent causing bovine spongiform …
consumption of meat products contaminated by the agent causing bovine spongiform …