Despite tremendous advances in the field of regenerative medicine, it still remains
challenging to repair the osteochondral interface and full-thickness articular cartilage …

Implantation of cell-laden scaffolds is a promising strategy for regenerating tissue that has
been damaged due to injury or disease. However, the act of implantation initiates an acute …

Cartilage degeneration with osteoarthritis (OA) is believed to involve the activities of
interleukin‐1 (IL‐1), which exists as alpha and beta isoforms. The goal of this study was to …

OBJECTIVE: Osteoarthritis is a disease process of cellular degradation of articular cartilage
caused by mechanical loads and inflammatory cytokines. We studied the cellular response …

Objective To determine differences in the metabolism of proteoglycans and the gene
expression of proteinases and their inhibitors between patellar tendons exhibiting chronic …

Previous studies showed that human nasal chondrocytes (HNC) exhibit higher proliferation
and chondrogenic capacity as compared to human articular chondrocytes (HAC). To …

Cells within cartilaginous tissues are mechanosensitive and thus require mechanical
loading for regulation of tissue homeostasis and metabolism. Mechanical loading plays …

OBJECTIVE: Meniscal tears are a common knee injury and increased levels of interleukin-1
(IL-1) have been measured in injured and degenerated joints. Studies have shown that IL-1 …

In articular cartilage, chondrocytes reside within a gel-like pericellular matrix (PCM). This
matrix provides a mechanical link through which joint loads are transmitted to chondrocytes …

Cartilage tissue engineering aims to repair damaged cartilage tissue in arthritic joints. As
arthritic joints have significantly higher levels of pro-inflammatory cytokines (such as IL-1β …