Mechanisms of specificity in protein phosphorylation
A typical protein kinase must recognize between one and a few hundred bona fide
phosphorylation sites in a background of∼ 700,000 potentially phosphorylatable residues …
phosphorylation sites in a background of∼ 700,000 potentially phosphorylatable residues …
Filling the void: proximity-based labeling of proteins in living cells
DI Kim, KJ Roux - Trends in cell biology, 2016 - cell.com
There are inherent limitations with traditional methods to study protein behavior or to
determine the constituency of proteins in discrete subcellular compartments. In response to …
determine the constituency of proteins in discrete subcellular compartments. In response to …
[HTML][HTML] Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling
Regulatory protein phosphorylation controls normal and pathophysiological signaling in
eukaryotic cells. Despite great advances in mass-spectrometry-based proteomics, the …
eukaryotic cells. Despite great advances in mass-spectrometry-based proteomics, the …
Site-selective tyrosine bioconjugation via photoredox catalysis for native-to-bioorthogonal protein transformation
The growing prevalence of synthetically modified proteins in pharmaceuticals and materials
has exposed the need for efficient strategies to enable chemical modifications with high site …
has exposed the need for efficient strategies to enable chemical modifications with high site …
Modular diazo compound for the bioreversible late-stage modification of proteins
We introduce a versatile strategy for the bioreversible modification of proteins. Our strategy
is based on a tricomponent molecule, synthesized in three steps, that incorporates a diazo …
is based on a tricomponent molecule, synthesized in three steps, that incorporates a diazo …
Secondary forces in protein folding
A complete inventory of the forces governing protein folding is critical for productive protein
modeling, including structure prediction and de novo design, as well as understanding …
modeling, including structure prediction and de novo design, as well as understanding …
Proximity‐dependent labeling methods for proteomic profiling in living cells: An update
JA Bosch, CL Chen, N Perrimon - Wiley Interdisciplinary …, 2021 - Wiley Online Library
Characterizing the proteome composition of organelles and subcellular regions of living
cells can facilitate the understanding of cellular organization as well as protein interactome …
cells can facilitate the understanding of cellular organization as well as protein interactome …
Leucyl-tRNA synthetase controls TORC1 via the EGO complex
G Bonfils, M Jaquenoud, S Bontron, C Ostrowicz… - Molecular cell, 2012 - cell.com
The target of rapamycin complex 1 (TORC1) is an essential regulator of eukaryotic cell
growth that responds to growth factors, energy levels, and amino acids. The mechanisms …
growth that responds to growth factors, energy levels, and amino acids. The mechanisms …
The GENCODE pseudogene resource
Background Pseudogenes have long been considered as nonfunctional genomic
sequences. However, recent evidence suggests that many of them might have some form of …
sequences. However, recent evidence suggests that many of them might have some form of …
Comparative chloroplast genomics: analyses including new sequences from the angiosperms Nuphar advena and Ranunculus macranthus
LA Raubeson, R Peery, TW Chumley, C Dziubek… - BMC genomics, 2007 - Springer
Background The number of completely sequenced plastid genomes available is growing
rapidly. This array of sequences presents new opportunities to perform comparative …
rapidly. This array of sequences presents new opportunities to perform comparative …