Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …

There is no standard definition for trauma-induced coagulopathy (TIC). However, it could be
defined as an abnormal hemostatic response secondary to trauma. The terms “early TIC” …

Hypercoagulability can occur after severe tissue injury, that is likely related to tissue factor
exposure and impaired endothelial release of tissue plasminogen activator (tPA). In contrast …

Objective Sepsis is the leading cause of death in intensive care units, and sepsis after
trauma is associated with increased mortality rates. However, the characteristics of sepsis …

Introduction Low‐titer group O whole blood (LTOWB) is being increasingly transfused to
injured patients. This study evaluated a range of clinical outcomes to determine if receipt of …

BACKGROUND This pilot assessed transfusion requirements during resuscitation with
whole blood followed by standard component therapy (CT) versus CT alone, during a …

Background Traumatic injury results in both physical and physiologic insult. Successful care
of the trauma patient depends upon timely correction of both physical and biochemical …

BACKGROUND Females are hypercoagulable and have survival benefit in trauma-induced
coagulopathy (TIC). The mechanism for this sex-specific hypercoagulability is unknown …

Abstract Purpose The Sex Differences in Radiation Research workshop addressed the role
of sex as a confounder in radiation research and its implication in real-world radiological …

Background Platelets are part of innate immunity and comprise the cellular portion of
hemostasis. Platelets express sex hormone receptors on their plasma membrane and sex …