Abstract The Ca2+-sensing receptor (CaSR) is a dimeric family CG protein-coupled receptor
that is expressed in calcitropic tissues such as the parathyroid glands and the kidneys and …

G-protein-coupled receptors (GPCRs) are key cell-surface proteins that transduce external
environmental cues into biochemical signals across the membrane. GPCRs are intrinsically …

Extracellular phosphate regulates its own renal excretion by eliciting concentration-
dependent secretion of parathyroid hormone (PTH). However, the phosphate-sensing …

The calcium-sensing receptor (CaSR), a cell-surface sensor for Ca2+, is the master
regulator of calcium homeostasis in humans and is the target of calcimimetic drugs for the …

Vertebrate glycoproteins and glycolipids are synthesized in complex biosynthetic pathways
localized predominantly within membrane compartments of the secretory pathway. The …

The human calcium-sensing receptor (CaSR) detects fluctuations in the extracellular Ca2+
concentration and maintains Ca2+ homeostasis,. It also mediates diverse cellular processes …

Inorganic phosphate (Pi) is essential for signal transduction and cell metabolism, and is also
an essential structural component of the extracellular matrix of the skeleton. Pi is sensed in …

A novel calcium-binding peptide from bovine bone collagen hydrolysate was screened
based on a new target—the calcium-sensing receptor (CaSR), and its chelation mechanism …

Groundbreaking structural and spectroscopic studies of class AG protein-coupled receptors
(GPCRs), such as rhodopsin and the β 2 adrenergic receptor, have provided a picture of …

The taste receptor type 1 (T1r) family perceives 'palatable'tastes. These receptors function as
T1r2-T1r3 and T1r1-T1r3 heterodimers to recognize a wide array of sweet and umami …