During the billions of years of the evolutionary journey, primitive polymers, involved in proto
metabolic pathways with low catalytic activity, played critical roles in the emergence of …

Lipopeptides are amphiphilic peptides in which an aliphatic chain is attached to either the C
or N terminus of peptides. Their self-assembly—into micelles, vesicles, nanotubes, fibres or …

Enzymes fold into unique three-dimensional structures to distribute their reactive amino acid
residues, but environmental changes can disrupt their essential folding and lead to …

Enzymes are highly evolved catalysts that perform their tasks with high efficiency. 1 Hence,
they may constitute a very attractive reference in the development of a synthetic catalyst. The …

Hydrolytic nanozymes, as promising alternatives to hydrolytic enzymes, can efficiently
catalyze the hydrolysis reactions and overcome the operating window limitations of natural …

Peptides and their conjugates (to lipids, bulky N-terminals, or other groups) can self-
assemble into nanostructures such as fibrils, nanotubes, coiled coil bundles, and micelles …

Chemical reactions require close physical contact between reactants, catalysts, and
intermediates to proceed. In a bulk homogeneous solution, this is often governed by random …

Hydrophobic environments have been identified as one of the main parameters affecting the
catalytic performance of artificial catalytic triads but are often ignored as an approach to …

Single site catalysts provide a unique platform for mimicking natural enzyme due to their
tunable interaction between metal center and coordinated ligand. However, most works …

The combinatorial space of an enzyme sequence has astronomical possibilities and
exploring it with contemporary experimental techniques is arduous and often ineffective …