Recent advances in delivery of drug–nucleic acid combinations for cancer treatment

J Li, Y Wang, Y Zhu, D Oupický - Journal of controlled release, 2013 - Elsevier
Cancer treatment that uses a combination of approaches with the ability to affect multiple
disease pathways has been proven highly effective in the treatment of many cancers …

[HTML][HTML] Advanced strategies for nucleic acids and small-molecular drugs in combined anticancer therapy

C Qiu, Y Wu, Q Shi, Q Guo, J Zhang… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Cancer has been considered as complex malignant consequence of genetic mutations that
control the cellular proliferation, differentiation and homeostasis, thus making tumor …

Lipid prodrug nanocarriers in cancer therapy

S Mura, DT Bui, P Couvreur, J Nicolas - Journal of controlled release, 2015 - Elsevier
Application of nanotechnology in the medical field (ie, nanomedicine) plays an important
role in the development of novel drug delivery methods. Nanoscale drug delivery systems …

[HTML][HTML] The Synergistic Benefit of Combination Strategies Targeting Tumor Cell Polyamine Homeostasis

TA Liu, TM Stewart, RA Casero Jr - International Journal of Molecular …, 2024 - mdpi.com
Mammalian polyamines, including putrescine, spermidine, and spermine, are positively
charged amines that are essential for all living cells including neoplastic cells. An increasing …

Significance of TRAIL/Apo-2 ligand and its death receptors in apoptosis and necroptosis signalling: Implications for cancer-targeted therapeutics

A Maji, A Paul, A Sarkar, S Nahar, R Bhowmik… - Biochemical …, 2024 - Elsevier
The human immune defense system routinely expresses the tumour necrosis factor (TNF)-
related apoptosis-inducing ligand (TRAIL), which is the most prevalent element for antitumor …

Polyamines metabolism and breast cancer: state of the art and perspectives

M Cervelli, S Pietropaoli, F Signore… - Breast cancer research …, 2014 - Springer
Breast cancer (BC) is a common disease that generally occurs in women over the age of 50,
and the risk is especially high for women over 60 years of age. One of the major BC …

Biohybrid Microswimmers for Antibiotic Drug Delivery Based on a Thiol‐Sensitive Release Platform

T Studer, D Morina, IS Shchelik… - Chemistry–A European …, 2023 - Wiley Online Library
This study reports on the design and engineering of biohybrid microswimmers exploiting a
thiol‐mediated self‐immolative antibiotic release strategy. The design features a covalent …

Development of functional poly (amido amine) CXCR4 antagonists with the ability to mobilize leukocytes and deliver nucleic acids

Y Wang, ST Hazeldine, J Li… - Advanced healthcare …, 2015 - Wiley Online Library
CXCR4 chemokine receptor plays a crucial role in metastatic spread of multiple types of
cancer. The present study reports on synthesis of functional polymers based on newly …

Polyamine-based nanostructures share polyamine transport mechanisms with native polyamines and their analogues: Significance for polyamine-targeted therapy

CE Holbert, JR Foley, A Yu, T Murray Stewart… - Medical …, 2022 - mdpi.com
Polyamines are small polycationic alkylamines involved in many fundamental cellular
processes, including cell proliferation, survival, and protection from oxidative stress …

Convergent Synthesis of N-Linked Glycopeptides via Aminolysis of ω-Asp p-Nitrophenyl Thioesters in Solution

JJ Du, XF Gao, LM **n, Z Lei, Z Liu, J Guo - Organic letters, 2016 - ACS Publications
An efficient N-linked glycosylation reaction between glycosylamines and p-nitrophenyl
thioester peptides has been developed. The reaction conditions are mild and compatible …