Recent advances in delivery of drug–nucleic acid combinations for cancer treatment
Cancer treatment that uses a combination of approaches with the ability to affect multiple
disease pathways has been proven highly effective in the treatment of many cancers …
disease pathways has been proven highly effective in the treatment of many cancers …
[HTML][HTML] Advanced strategies for nucleic acids and small-molecular drugs in combined anticancer therapy
C Qiu, Y Wu, Q Shi, Q Guo, J Zhang… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Cancer has been considered as complex malignant consequence of genetic mutations that
control the cellular proliferation, differentiation and homeostasis, thus making tumor …
control the cellular proliferation, differentiation and homeostasis, thus making tumor …
Lipid prodrug nanocarriers in cancer therapy
Application of nanotechnology in the medical field (ie, nanomedicine) plays an important
role in the development of novel drug delivery methods. Nanoscale drug delivery systems …
role in the development of novel drug delivery methods. Nanoscale drug delivery systems …
[HTML][HTML] The Synergistic Benefit of Combination Strategies Targeting Tumor Cell Polyamine Homeostasis
TA Liu, TM Stewart, RA Casero Jr - International Journal of Molecular …, 2024 - mdpi.com
Mammalian polyamines, including putrescine, spermidine, and spermine, are positively
charged amines that are essential for all living cells including neoplastic cells. An increasing …
charged amines that are essential for all living cells including neoplastic cells. An increasing …
Significance of TRAIL/Apo-2 ligand and its death receptors in apoptosis and necroptosis signalling: Implications for cancer-targeted therapeutics
The human immune defense system routinely expresses the tumour necrosis factor (TNF)-
related apoptosis-inducing ligand (TRAIL), which is the most prevalent element for antitumor …
related apoptosis-inducing ligand (TRAIL), which is the most prevalent element for antitumor …
Polyamines metabolism and breast cancer: state of the art and perspectives
M Cervelli, S Pietropaoli, F Signore… - Breast cancer research …, 2014 - Springer
Breast cancer (BC) is a common disease that generally occurs in women over the age of 50,
and the risk is especially high for women over 60 years of age. One of the major BC …
and the risk is especially high for women over 60 years of age. One of the major BC …
Biohybrid Microswimmers for Antibiotic Drug Delivery Based on a Thiol‐Sensitive Release Platform
T Studer, D Morina, IS Shchelik… - Chemistry–A European …, 2023 - Wiley Online Library
This study reports on the design and engineering of biohybrid microswimmers exploiting a
thiol‐mediated self‐immolative antibiotic release strategy. The design features a covalent …
thiol‐mediated self‐immolative antibiotic release strategy. The design features a covalent …
Development of functional poly (amido amine) CXCR4 antagonists with the ability to mobilize leukocytes and deliver nucleic acids
Y Wang, ST Hazeldine, J Li… - Advanced healthcare …, 2015 - Wiley Online Library
CXCR4 chemokine receptor plays a crucial role in metastatic spread of multiple types of
cancer. The present study reports on synthesis of functional polymers based on newly …
cancer. The present study reports on synthesis of functional polymers based on newly …
Polyamine-based nanostructures share polyamine transport mechanisms with native polyamines and their analogues: Significance for polyamine-targeted therapy
CE Holbert, JR Foley, A Yu, T Murray Stewart… - Medical …, 2022 - mdpi.com
Polyamines are small polycationic alkylamines involved in many fundamental cellular
processes, including cell proliferation, survival, and protection from oxidative stress …
processes, including cell proliferation, survival, and protection from oxidative stress …
Convergent Synthesis of N-Linked Glycopeptides via Aminolysis of ω-Asp p-Nitrophenyl Thioesters in Solution
JJ Du, XF Gao, LM **n, Z Lei, Z Liu, J Guo - Organic letters, 2016 - ACS Publications
An efficient N-linked glycosylation reaction between glycosylamines and p-nitrophenyl
thioester peptides has been developed. The reaction conditions are mild and compatible …
thioester peptides has been developed. The reaction conditions are mild and compatible …