During an action potential, Ca 2+ entering a presynaptic terminal triggers synaptic vesicle
exocytosis and neurotransmitter release in less than a millisecond. How does Ca 2+ …

▪ Abstract Synaptic transmission is a dynamic process. Postsynaptic responses wax and
wane as presynaptic activity evolves. This prominent characteristic of chemical synaptic …

В монографии представлены литературные и собственные данные в области
изучения феномена пластичности синапсов в качестве составной части …

It has been known for more than 70 years that synaptic strength is dynamically regulated in a
use-dependent manner. At synapses with a low initial release probability, closely spaced …

The two universally required components of the intracellular membrane fusion machinery,
SNARE and SM (Sec1/Munc18-like) proteins, play complementary roles in fusion. Vesicular …

Most neuronal communication relies upon the synchronous release of neurotransmitters,
which occurs through synaptic vesicle exocytosis triggered by action potential invasion of a …

Upon entering a presynaptic terminal, an action potential opens Ca2+ channels, and
transiently increases the local Ca2+ concentration at the presynaptic active zone. Ca2+ then …

Synaptotagmin-1 and neuronal SNARE proteins have central roles in evoked synchronous
neurotransmitter release; however, it is unknown how they cooperate to trigger synaptic …

▪ Abstract Neurotransmitter release is mediated by exocytosis of synaptic vesicles at the
presynaptic active zone of nerve terminals. To support rapid and repeated rounds of release …

Plasma membrane wounds are repaired by a mechanism involving Ca 2+-regulated
exocytosis. Elevation in intracellular [Ca 2+] triggers fusion of lysosomes with the plasma …