Antimicrobial resistance (AMR) is one of the greatest threats to human health that, by 2050,
will lead to more deaths from bacterial infections than cancer. New antimicrobial agents …

The addition of O-linked-β-DN-acetylglucosamine (O-GlcNAc) onto serine and threonine
residues of nuclear and cytoplasmic proteins is an abundant, unique post-translational …

Through mechanistic work and rational design, we have developed the fastest
organometallic abiotic Cys bioconjugation. As a result, the developed organometallic Au (III) …

Here we report a nonenzymatic glycosylation reaction that builds axial S-glycosidic bonds
under biorelevant conditions. This strategy is enabled by the design and use of allyl glycosyl …

A major role for the intracellular post-translational modification O-GlcNAc appears to be the
inhibition of protein aggregation. Most of the previous studies in this area focused on O …

Protein O-linked β-N-acetylglucosamine modification (O-GlcNAcylation) plays a crucial role
in regulating essential cellular processes. The disruption of the homeostasis of O …

The modification of nuclear, cytoplasmic, and mitochondrial proteins by O-linked β-N-
acetylglucosamine (O-GlcNAc) is an essential post-translational modification common in …

Protein glycosylation is a key post-translational modification important to many facets of
biology. Glycosylation can have critical effects on protein conformation, uptake and …

Complex carbohydrates (glycans) are major players in all organisms due to their structural,
energy, and communication roles. This last essential role involves interacting and/or …

Modification of specific Ser and Thr residues of nucleocytoplasmic proteins with O-GlcNAc,
catalyzed by O-GlcNAc transferase (OGT), is an abundant posttranslational event essential …