Electrotherapies for glioblastoma

EPW Jenkins, A Finch, M Gerigk, IF Triantis… - Advanced …, 2021 - Wiley Online Library
Abstract Non‐thermal, intermediate frequency (100–500 kHz) electrotherapies present a
unique therapeutic strategy to treat malignant neoplasms. Here, pulsed electric fields (PEFs) …

A review on differences in effects on normal and malignant cells and tissues to electroporation-based therapies: A focus on calcium electroporation

SK Frandsen, J Gehl - Technology in cancer research & …, 2018 - journals.sagepub.com
Calcium electroporation is a potential novel anticancer treatment, where high concentrations
of calcium are introduced into the cell cytosol by electroporation. This is a method where …

Electroporation and cell killing by milli-to nanosecond pulses and avoiding neuromuscular stimulation in cancer ablation

E Gudvangen, V Kim, V Novickij, F Battista… - Scientific Reports, 2022 - nature.com
Ablation therapies aim at eradication of tumors with minimal impact on surrounding healthy
tissues. Conventional pulsed electric field (PEF) treatments cause pain and muscle …

Dynamics of cell death after conventional IRE and H-FIRE treatments

B Mercadal, N Beitel-White, KN Aycock… - Annals of biomedical …, 2020 - Springer
High-frequency irreversible electroporation (H-FIRE) has emerged as an alternative to
conventional irreversible electroporation (IRE) to overcome the issues associated with …

Experimental high-frequency irreversible electroporation using a single-needle delivery approach for nonthermal pancreatic ablation in vivo

TJ O'Brien, M Passeri, MF Lorenzo, JK Sulzer… - Journal of Vascular and …, 2019 - Elsevier
Purpose To investigate the feasibility of single-needle high-frequency irreversible
electroporation (SN-HFIRE) to create reproducible tissue ablations in an in vivo pancreatic …

Interference targeting of bipolar nanosecond electric pulses for spatially focused electroporation, electrostimulation, and tissue ablation

AG Pakhomov, E Gudvangen, S **ao, I Semenov - Bioelectrochemistry, 2021 - Elsevier
Stimulation and electroporation by nanosecond electric pulses (nsEP) are distinguished by
a phenomenon of bipolar cancellation, which stands for a reduced efficiency of bipolar …

A comprehensive characterization of parameters affecting high-frequency irreversible electroporation lesions

T Miklovic, EL Latouche, MR DeWitt… - Annals of biomedical …, 2017 - Springer
Several focal therapies are being investigated clinically to treat tumors in which surgery is
contraindicated. Many of these ablation techniques, such as radiofrequency ablation and …

[PDF][PDF] The use of high-frequency short bipolar pulses in cisplatin electrochemotherapy in vitro

M Scuderi, M Rebersek, D Miklavcic… - Radiology and …, 2019 - sciendo.com
Background. In electrochemotherapy (ECT), chemotherapeutics are first administered,
followed by short 100 µs monopolar pulses. However, these pulses cause pain and muscle …

Ultrasound‐guided percutaneous high‐frequency irreversible electroporation in porcine livers using four electrode needles: A feasibility and safety study

CT Li, GD Zhao, WB Zou, ZH Zhang, Y Zhao… - Cancer …, 2024 - Wiley Online Library
Background Malignant liver tumors seriously endanger human health. Among different
therapeutic approaches, high‐frequency irreversible electroporation (H‐FIRE) is a recently …

Optimization of a single insertion electrode array for the creation of clinically relevant ablations using high-frequency irreversible electroporation

MB Sano, MR DeWitt, SD Teeter, L **ng - Computers in Biology and …, 2018 - Elsevier
High-frequency irreversible electroporation (H-FIRE) is an emerging ablation modality,
delivering rapid bursts of bipolar microsecond-duration electrical pulses to non-thermally …