Generalized myasthenia gravis: classification, clinical presentation, natural history, and epidemiology

MK Hehir, NJ Silvestri - Neurologic clinics, 2018 - neurologic.theclinics.com
Myasthenia gravis (MG) is the most common disorder of the neuromuscular junction. It is the
prototypic autoimmune disease most commonly caused by antibodies to the acetylcholine …

Myasthenia gravis: a clinical-immunological update

S Binks, A Vincent, J Palace - Journal of neurology, 2016 - Springer
Myasthenia gravis (MG) is the archetypic disorder of both the neuromuscular junction and
autoantibody-mediated disease. In most patients, IgG1-dominant antibodies to acetylcholine …

Safety and clinical activity of autologous RNA chimeric antigen receptor T-cell therapy in myasthenia gravis (MG-001): a prospective, multicentre, open-label, non …

V Granit, M Benatar, M Kurtoglu, MD Miljković… - The Lancet …, 2023 - thelancet.com
Background Chimeric antigen receptor (CAR) T cells are highly effective in treating
haematological malignancies, but associated toxicities and the need for lymphodepletion …

Management of juvenile myasthenia gravis

K O'Connell, S Ramdas, J Palace - Frontiers in neurology, 2020 - frontiersin.org
Juvenile Myasthenia Gravis (JMG) is a rare disorder, defined as myasthenia gravis in
children younger than 18 years of age. While clinical phenotypes are similar to adults, there …

Clinical features of LRP4/agrin‐antibody–positive myasthenia gravis: A multicenter study

MH Rivner, BM Quarles, JX Pan, Z Yu… - Muscle & …, 2020 - Wiley Online Library
Introduction Our aim in this study was to identify the prevalence and clinical characteristics of
LRP4/agrin‐antibody–positive double‐seronegative myasthenia gravis (DNMG). Methods …

Heterogeneity of acetylcholine receptor autoantibody–mediated complement activity in patients with myasthenia gravis

AH Obaid, C Zografou, DD Vadysirisack… - Neurology …, 2022 - neurology.org
Background and Objectives Autoantibodies targeting the acetylcholine receptor (AChR),
found in patients with myasthenia gravis (MG), mediate pathology through 3 mechanisms …

Autoantibody-producing plasmablasts after B cell depletion identified in muscle-specific kinase myasthenia gravis

P Stathopoulos, A Kumar, RJ Nowak… - JCI insight, 2017 - pmc.ncbi.nlm.nih.gov
Myasthenia gravis (MG) is a B cell–mediated autoimmune disorder of neuromuscular
transmission. Pathogenic autoantibodies to muscle-specific tyrosine kinase (MuSK) can be …

[HTML][HTML] Autoimmunity to neuronal nicotinic acetylcholine receptors

M Pechlivanidou, E Ninou, K Karagiorgou… - Pharmacological …, 2023 - Elsevier
Nicotinic acetylcholine receptors (nAChRs) are widely expressed in many and diverse cell
types, participating in various functions of cells, tissues and systems. In this review, we focus …

Diagnosis and management of myasthenia gravis

MK Hehir, Y Li - CONTINUUM: Lifelong Learning in Neurology, 2022 - journals.lww.com
Diagnosis and Management of Myasthenia Gravis : CONTINUUM: Lifelong Learning in
Neurology Account Register Activate Subscription Help Subscribe American Academy of …

Clinical value of cell-based assays in the characterisation of seronegative myasthenia gravis

V Damato, G Spagni, G Monte, M Woodhall… - Journal of Neurology …, 2022 - jnnp.bmj.com
Objective Patients with myasthenia gravis without acetylcholine receptor (AChR) or muscle-
specific kinase (MuSK) antibodies detected by radioimmunoprecipitation assays (RIAs) are …