Gram-positive bacteria are responsible for a broad range of infectious diseases, and the
emergency and wide spread of drug-resistant Gram-positive pathogens including MRSA …

Gram‐negative pathogens represent a significant global health threat, while the emergency
and widespread of drug resistance make the situation even worse. As “privileged building …

Pancreatic triacylglycerol lipase (PL) has been reported as an interesting pharmacological
target for the management of dyslipidemia, atherosclerosis, and obesity. In the current study …

Abstract Novel 1‐(ethyl/methyl)‐7‐(p‐methoxybenzyl amino) and 7‐amino‐6‐
fluoroquinolone‐boron difluoride complexes were synthesized, and their biological activity …

The synthesis of new 7-(halophenylamino)-1-cyclopropyl-6-fluoro-8-nitro-4-oxo-1, 4-
dihydroquinoline-3-carboxylic acid derivatives is described. Substitution of quinolonic …

This research paper aims the preparation of substituted tetrahydroquino [7, 8-b][1, 4]
benzodiazepine-3-carboxylic acids 4a, 4b and 4c. Reaction of 7-chloro-1-cyclopropyl-6 …

Even if many antimicrobials have been created over the years, the increasing bacterial
resistance has made the search for new agents that inhibit bacterial cell growth an unmet …

Quinolones represent a successful class of broadspectrum anti-microbial agents used in the
prevention and treatment of a variety of infections. 1-6 Nowadays, fluoroquinolones (eg …

Direct interaction of dithizone with 7-chloro-6-fluoro-8-nitro-4-oxoquinoline-3-carboxylic acid
or with its ester delivered the corresponding novel 1, 3, 4-thiadiazino [5, 6-h] quinoline 3 …

Fluoroquinolones are clinically successful antibacterial agents. In this work a series of novel
7-substituted anilino-8-nitrofluoroquinolone esters (3-9), acids (10-16) and 8-amino reduced …