Stiffness sensing by cells

PA Janmey, DA Fletcher… - Physiological …, 2020 - journals.physiology.org
Physical stimuli are essential for the function of eukaryotic cells, and changes in physical
signals are important elements in normal tissue development as well as in disease initiation …

Fibrin formation, structure and properties

JW Weisel, RI Litvinov - Fibrous proteins: structures and mechanisms, 2017 - Springer
Fibrinogen and fibrin are essential for hemostasis and are major factors in thrombosis,
wound healing, and several other biological functions and pathological conditions. The X …

Biodegradable hydrogel with thermo-response and hemostatic effect for photothermal enhanced anti-infective therapy

C Cao, N Yang, Y Zhao, D Yang, Y Hu, D Yang, X Song… - Nano Today, 2021 - Elsevier
Massive bleeding and infectious complication remain the leading cause of worldwide
trauma deaths. To tackle this issue, a platelet-inspired degradable antibacterial hydrogel …

Biomaterials and advanced technologies for hemostatic management of bleeding

DSA Hickman, CL Pawlowski, UDS Sekhon… - Advanced …, 2018 - Wiley Online Library
Bleeding complications arising from trauma, surgery, and as congenital, disease‐
associated, or drug‐induced blood disorders can cause significant morbidities and …

Superhydrophobic hemostatic nanofiber composites for fast clotting and minimal adhesion

Z Li, A Milionis, Y Zheng, M Yee, L Codispoti… - Nature …, 2019 - nature.com
Hemostatic materials are of great importance in medicine. However, their successful
implementation is still challenging as it depends on two, often counteracting, attributes; …

Trauma-induced coagulopathy

EE Moore, HB Moore, LZ Kornblith, MD Neal… - Nature reviews Disease …, 2021 - nature.com
Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …

Migrating platelets are mechano-scavengers that collect and bundle bacteria

F Gaertner, Z Ahmad, G Rosenberger, S Fan, L Nicolai… - Cell, 2017 - cell.com
Blood platelets are critical for hemostasis and thrombosis and play diverse roles during
immune responses. Despite these versatile tasks in mammalian biology, their skills on a …

Modeling semiflexible polymer networks

CP Broedersz, FC MacKintosh - Reviews of Modern Physics, 2014 - APS
This is an overview of theoretical approaches to semiflexible polymers and their networks.
Such semiflexible polymers have large bending rigidities that can compete with the entropic …

Broken detailed balance and non-equilibrium dynamics in living systems: a review

FS Gnesotto, F Mura, J Gladrow… - Reports on Progress in …, 2018 - iopscience.iop.org
Living systems operate far from thermodynamic equilibrium. Enzymatic activity can induce
broken detailed balance at the molecular scale. This molecular scale breaking of detailed …

Receptor-mediated cell mechanosensing

Y Chen, L Ju, M Rushdi, C Ge… - Molecular biology of the …, 2017 - Am Soc Cell Biol
Mechanosensing describes the ability of a cell to sense mechanical cues of its
microenvironment, including not only all components of force, stress, and strain but also …