Single-molecule force spectroscopy with the atomic force microscope provides molecular
level insights into protein function, allowing researchers to reconstruct energy landscapes …

One of the most exciting developments in the field of biological physics in recent years is the
ability to manipulate single molecules and probe their properties and function. Since its …

Much has been learned in the past decades about molecular force generation. Single-
molecule techniques, such as atomic force microscopy, single-molecule fluorescence …

In recent years single molecule force spectroscopy has emerged as a powerful new tool to
explore the mechanical stability and folding pathways of individual proteins. This technique …

Kinetic bulk and single molecule folding experiments characterize barrier properties but the
shape of folding landscapes between barrier top and native state is difficult to access. Here …

In contrast to postmitotic or short-lived somatic cells, tissue-specific stem cells must persist
and function throughout life to ensure tissue homeostasis and repair. The enormous …

Cells exert, sense, and respond to the different physical forces through diverse mechanisms
and translating them into biochemical signals. The adhesion of cells is crucial in various …

The transition of single-molecule fluorescence detection and imaging from in vitro to living
cells has greatly enriched our knowledge on the behavior of single biomolecules in their …

Coiled coils are important nanomechanical building blocks in biological and biomimetic
materials. A mechanistic molecular understanding of their structural response to mechanical …

Folding of small proteins often occurs in a two-state manner and is well understood both
experimentally and theoretically. However, many proteins are much larger and often …