Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

Mucosal immune response in biology, disease prevention and treatment

X Zhou, Y Wu, Z Zhu, C Lu, C Zhang, L Zeng… - … and Targeted Therapy, 2025 - nature.com
The mucosal immune system, as the most extensive peripheral immune network, serves as
the frontline defense against a myriad of microbial and dietary antigens. It is crucial in …

A multivalent and thermostable nanobody neutralizing SARS-CoV-2 omicron (B. 1.1. 529)

Y Lu, Q Li, H Fan, C Liao, J Zhang, H Hu… - International Journal …, 2023 - Taylor & Francis
Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron
variants have risen to dominance, which contains far more mutations in the spike protein in …

Broad and Durable Humoral Responses Following Single Hydrogel Immunization of SARS‐CoV‐2 Subunit Vaccine

BS Ou, OM Saouaf, J Yan, TUJ Bruun… - Advanced …, 2023 - Wiley Online Library
Most vaccines require several immunizations to induce robust immunity, and indeed, most
SARS‐CoV‐2 vaccines require an initial two‐shot regimen followed by several boosters to …

COVID-19 vaccines based on viral nanoparticles displaying a conserved B-cell epitope show potent immunogenicity and a long-lasting antibody response

JF Affonso de Oliveira, Z Zhao, Y ** Strategies for Neutralizing Monoclonal Antibody Therapy in the Omicron Era of COVID-19
Z Ren, C Shen, J Peng - Viruses, 2023 - mdpi.com
The monoclonal antibody (mAb)-based treatment is a highly valued therapy against COVID-
19, especially for individuals who may not have strong immune responses to the vaccine …

A stabilized MERS-CoV spike ferritin nanoparticle vaccine elicits robust and protective neutralizing antibody responses

AE Powell, H Caruso, S Park, JL Chen, J O'Rear… - bioRxiv, 2024 - biorxiv.org
Middle East respiratory syndrome coronavirus (MERS-CoV) was first identified as a human
pathogenic virus in 2012 and is causing ongoing sporadic infections as well as outbreak …

Research on the global trends of COVID-19 associated acute kidney injury: a bibliometric analysis

W Zhao, R Tan, J Gao, H Su, L Wang, J Liu - Renal Failure, 2024 - Taylor & Francis
Critically ill COVID-19 patients may exhibit various clinical symptoms of renal dysfunction
including severe Acute Kidney Injury (AKI). Currently, there is a lack of bibliometric analyses …