Heparan sulfate proteoglycans (HSPGs) encompass a group of glycoproteins composed of
unbranched negatively charged heparan sulfate (HS) chains covalently attached to a core …

Cell surface proteoglycans are known to be important regulators of many aspects of cell
behavior. The principal family of transmembrane proteoglycans is the syndecans, of which …

Filtration barrier injury induced by high glucose (HG) levels leads to the development of
diabetic nephropathy. The endothelial glycocalyx plays a critical role in glomerular barrier …

The extracellular matrix (ECM) is a structural framework that has many important
physiological functions which include maintaining tissue structure and integrity, serving as a …

Syndecans are transmembrane heparan sulfate proteoglycans present on most mammalian
cell surfaces. They have a long evolutionary history, a single syndecan gene being …

Heparanase (Hpa1) is expressed by tumor cells and cells of the tumor microenvironment
and functions extracellularly to remodel the extracellular matrix (ECM) and regulate the …

Multiple myeloma (MM) is an incurable hematological disease characterized by the
uncontrolledgrowth of plasma cells primarily in the bone marrow. Although its treatment …

The syndecans are the major family of transmembrane proteoglycans, usually bearing
multiple heparan sulfate chains. They are present on virtually all nucleated cells of …

HPSE2, the gene‐encoding heparanase 2 (Hpa2), is mutated in urofacial syndrome (UFS),
a rare autosomal recessive congenital disease attributed to peripheral neuropathy. Hpa2 …

This narrative review provides a comprehensive examination of the complex interplay
between inflammatory arthritis (IA) and cardiovascular pathology. It particularly illuminates …