Immunobiology and pathogenesis of hepatitis B virus infection
Hepatitis B virus (HBV) is a non-cytopathic, hepatotropic virus with the potential to cause a
persistent infection, ultimately leading to cirrhosis and hepatocellular carcinoma. Over the …
persistent infection, ultimately leading to cirrhosis and hepatocellular carcinoma. Over the …
Therapeutic potential of Toll-like receptor 9 activation
AM Krieg - Nature reviews Drug discovery, 2006 - nature.com
In the decade since the discovery that mouse B cells respond to certain unmethylated CpG
dinucleotides in bacterial DNA, a specific receptor for these'CpG motifs' has been identified …
dinucleotides in bacterial DNA, a specific receptor for these'CpG motifs' has been identified …
A global scientific strategy to cure hepatitis B
Chronic hepatitis B virus (HBV) infection is a global public health challenge on the same
scale as tuberculosis, HIV, and malaria. The International Coalition to Eliminate HBV (ICE …
scale as tuberculosis, HIV, and malaria. The International Coalition to Eliminate HBV (ICE …
TLR4 enhances TGF-β signaling and hepatic fibrosis
E Seki, S De Minicis, CH Österreicher, J Kluwe… - Nature medicine, 2007 - nature.com
Hepatic injury is associated with a defective intestinal barrier and increased hepatic
exposure to bacterial products. Here we report that the intestinal bacterial microflora and a …
exposure to bacterial products. Here we report that the intestinal bacterial microflora and a …
Toll-like receptors in antiviral innate immunity
SN Lester, K Li - Journal of molecular biology, 2014 - Elsevier
Toll-like receptors (TLRs) are fundamental sensor molecules of the host innate immune
system, which detect conserved molecular signatures of a wide range of microbial …
system, which detect conserved molecular signatures of a wide range of microbial …
Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease
X Cao - Nature Reviews Immunology, 2016 - nature.com
In the initiation of innate immune responses against pathogens, pattern-recognition
receptors (PRRs) have an essential role in recognizing specific components of …
receptors (PRRs) have an essential role in recognizing specific components of …
Pathogenic mechanisms in HBV-and HCV-associated hepatocellular carcinoma
A Arzumanyan, HM Reis, MA Feitelson - Nature Reviews Cancer, 2013 - nature.com
Hepatocellular carcinoma (HCC) is a highly lethal cancer, with increasing worldwide
incidence, that is mainly associated with chronic hepatitis B virus (HBV) and/or hepatitis C …
incidence, that is mainly associated with chronic hepatitis B virus (HBV) and/or hepatitis C …
Getting to HBV cure: The promising paths forward
Chronic HBV infection is a global public health burden estimated to impact nearly 300
million persons worldwide. Despite the advent of potent antiviral agents that effectively …
million persons worldwide. Despite the advent of potent antiviral agents that effectively …
[PDF][PDF] Liver: an organ with predominant innate immunity
Blood circulating from the intestines to the liver is rich in bacterial products, environmental
toxins, and food antigens. To effectively and quickly defend against potentially toxic agents …
toxins, and food antigens. To effectively and quickly defend against potentially toxic agents …
Republished: Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection
A Bertoletti, C Ferrari - Postgraduate Medical Journal, 2013 - academic.oup.com
Abstract Knowledge of the immunological events necessary to control hepatitis B virus
(HBV) infection has accelerated in recent years, but their translation towards therapeutic …
(HBV) infection has accelerated in recent years, but their translation towards therapeutic …