Curcumin, a yellow pigment in the Indian spice Turmeric (Curcuma longa), which is
chemically known as diferuloylmethane, was first isolated exactly two centuries ago in 1815 …

Carotenoids and retinoids have several similar biological activities such as antioxidant
properties, the inhibition of malignant tumour growth and the induction of apoptosis …

Tannins are a heterogeneous group of high MW, water‐soluble, polyphenolic compounds,
naturally present in cereals, leguminous seeds and, predominantly, in many fruits and …

Macrolides represent a large family of protein synthesis inhibitors of great clinical interest
due to their applicability to human medicine. Macrolides are composed of a macrocyclic …

Phytoestrogens are plant‐derived dietary compounds with structural similarity to 17‐β‐
oestradiol (E2), the primary female sex hormone. This structural similarity to E2 enables …

Resveratrol increases the production of nitric oxide (NO) in endothelial cells by upregulating
the expression of endothelial NO synthase (eNOS), stimulating eNOS enzymatic activity, and …

The antioxidant effects of resveratrol (3, 5, 4'‐trihydroxy‐trans‐stilbene) contribute
substantially to the health benefits of this compound. Resveratrol has been shown to be a …

Cardiovascular diseases are major contributors to global deaths and disability‐adjusted life
years, with hypertension a significant risk factor for all causes of death. The endothelium that …

Systemically administered opioids are among the most powerful analgesics for treating
severe pain. Several negative side effects (respiratory depression, addiction, nausea and …

Drug repurposing holds the potential to bring medications with known safety profiles to new
patient populations. Numerous examples exist for the identification of new indications for …