Circadian clocks are endogenous oscillators that control 24-hour physiological and
behavioural processes in organisms. These cell-autonomous clocks are composed of a …

Bipolar disorder (BD) is the sixth leading cause of disability in the world according to the
World Health Organization and affects nearly six million (∼ 2.5% of the population) adults in …

The mammalian circadian clock is based on a transcription–translation feedback loop
(TTFL) in which CLOCK and BMAL1 proteins act as transcriptional activators of …

The basic helix–loop–helix (bHLH) family of transcription factors recognizes DNA motifs
known as E-boxes (CANNTG) and includes 108 members. Here we investigate how …

Circular data are common in biological studies. The most fundamental question that can be
asked of a sample of circular data is whether it suggests that the underlying population is …

The molecular circadian clock in mammals is generated from transcriptional activation by the
bHLH-PAS transcription factor CLOCK–BMAL1 and subsequent repression by PERIOD and …

The cell biology of circadian clocks is still in its infancy. Here, we describe an efficient
strategy for generating knock-in reporter cell lines using CRISPR technology that is …

Cryptochromes are evolutionarily related to the light‐dependent DNA repair enzyme
photolyase, serving as major regulators of circadian rhythms in insects and vertebrate …

Memory impairment is the main feature of Alzheimer's disease (AD). Initial impairments
originate in the temporal lobe area and propagate throughout the brain in a sequential …

The basic helix–loop–helix PAS domain (bHLH-PAS) transcription factor CLOCK: BMAL1
(brain and muscle Arnt-like protein 1) sits at the core of the mammalian circadian …