The purpose of this article is to provide a synopsis of the current medical understanding of
knee osteoarthritis. We describe the prevalence, causes and associated risk factors …

The impairment of articular cartilage due to traumatic incidents or osteoarthritis has posed
significant challenges for healthcare practitioners, researchers, and individuals suffering …

Knee osteoarthritis (OA) is believed to be highly prevalent today because of recent
increases in life expectancy and body mass index (BMI), but this assumption has not been …

Background Obesity increases the risk of several chronic diseases, but the extent to which
the obesity-related loss of disease-free years varies by lifestyle category and across …

Metabolism is important for cartilage and synovial joint function. Under adverse
microenvironmental conditions, mammalian cells undergo a switch in cell metabolism from a …

Knee osteoarthritis is one of the most common degenerative diseases causing disability in
elderly patients. Osteoarthritis is an increasing problem for ageing populations, such as that …

Leptin is one of the most relevant factors secreted by adipose tissue and the forerunner of a
class of molecules collectively called adipokines. Initially discovered in 1994, its crucial role …

Osteoarthritis (OA) has been thought of as a disease of cartilage that can be effectively
treated surgically at severe stages with joint arthroplasty. Today, OA is considered a whole …

The prevalence of osteoarthritis (OA) is rising for reasons that are not fully understood. In this
Opinion article, we review the possibility that OA is an evolutionary mismatch disease, which …

Objectives Type 2 diabetes mellitus (T2DM) and osteoarthritis (OA) are common diseases
that frequently co-exist, along with overweight/obesity. While the mechanical impact of …