Widmann, Christian, Spencer Gibson, Matthew B. Jarpe, and Gary L. Johnson. Mitogen-
Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human …

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Publisher Summary The chapter introduces the mitogen-activated protein (MAP) kinase
(MAPK) module. The identification of MAP kinase pathways exemplifies the power of …

The highly conserved and ubiquitously expressed 14-3-3 family of proteins bind to a variety
of proteins involved in signal transduction and cell cycle regulation. The nature and …

Signal transduction pathways that respond to external signals through the MAP kinase
family of protein kinases are involved in diverse responses in eukaryotic cells. MAP kinases …

The molecular mechanisms by which ovarian hormones stimulate growth of breast tumors
are unclear. It has been reported previously that estrogens activate the signal‐transducing …

MAP kinases phosphorylate specific groups of substrate proteins. Here we show that the
amino acid sequence FXFP is an evolutionarily conserved docking site that mediates ERK …

The mitogen-activated protein kinase (MAPK) cascade is one of the most important of the
intracellular signaling pathways that play a crucial role in cell proliferation, cell differentiation …

THE protein Raf-1, a key mediator of mitogenesis and differentia-tion, associates with p21*"
a5 (refs 1-3). However, the regulation of the serine/threonine kinase activity of Raf-1 is still …

Phosphatidylinositol (Pl)-3 kinase is one of many enzymes stimulated by growth factors. A
constitutively activated mutant, p110*, that functions independently of growth factor …