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Understanding the development of tuberculous granulomas: insights into host protection and pathogenesis, a review in humans and animals
J Lyu, DE Narum, SL Baldwin, SE Larsen… - Frontiers in …, 2024 - frontiersin.org
Granulomas, organized aggregates of immune cells which form in response to
Mycobacterium tuberculosis (Mtb), are characteristic but not exclusive of tuberculosis (TB) …
Mycobacterium tuberculosis (Mtb), are characteristic but not exclusive of tuberculosis (TB) …
[HTML][HTML] Pathogenic role for CD101-negative neutrophils in the type I interferon-mediated immunopathogenesis of tuberculosis
Neutrophils are vital for immunity against Mycobacterium tuberculosis (Mtb), the causative
agent of tuberculosis (TB), yet their heterogeneous nature suggests a complex role in TB …
agent of tuberculosis (TB), yet their heterogeneous nature suggests a complex role in TB …
Single cell autofluorescence imaging reveals immediate metabolic shifts of neutrophils with activation across biological systems
Neutrophils, the most abundant leukocytes in human peripheral circulation, are crucial for
the innate immune response. They are typically quiescent but rapidly activate in response to …
the innate immune response. They are typically quiescent but rapidly activate in response to …
CXCL9, granzyme B and TNF-α orchestrate protective in vitro granulomatous responses across Mycobacterium tuberculosis complex lineages
A Arbués, S Schmidiger, M Reinhard, S Borrell… - bioRxiv, 2024 - biorxiv.org
The members of the Mycobacterium tuberculosis complex (MTBC) causing human
tuberculosis comprise ten phylogenetic lineages that differ in their geographical distribution …
tuberculosis comprise ten phylogenetic lineages that differ in their geographical distribution …
Fatty acid metabolism in neutrophils promotes lung damage and bacterial replication during tuberculosis
Mycobacterium tuberculosis (Mtb) infection induces a marked influx of neutrophils into the
lungs, which intensifies the severity of tuberculosis (TB). The metabolic state of neutrophils …
lungs, which intensifies the severity of tuberculosis (TB). The metabolic state of neutrophils …