Mammalian orthoreoviruses (reoviruses) are prototype members of the Reoviridae family of
nonenveloped viruses. Reoviruses contain ten double-stranded RNA gene segments …

To achieve cell entry, many nonenveloped viruses must transform from a dormant to a
primed state. In contrast to the membrane fusion mechanism of enveloped viruses (eg …

Viruses that specifically replicate in tumor over normal cells offer promising cancer
therapies. Oncolytic viruses (OV) not only kill the tumor cells directly; they also promote anti …

Ebolavirus (EBOV) entry into cells requires proteolytic disassembly of the viral glycoprotein,
GP. This proteolytic processing, unusually extensive for an enveloped virus entry protein, is …

Upon viral infection, an arms-race between the cellular intrinsic innate immune system and
viral replication is established. To win this race, viruses have established multiple strategies …

The outer capsid of the nonenveloped mammalian reovirus contains 200 trimers of the μ1
protein, each complexed with three copies of the protector protein σ3. Conformational …

Polarized epithelial cells that line the digestive, respiratory, and genitourinary tracts form a
barrier that many viruses must breach to infect their hosts. Current understanding of cell …

Virus-host interactions play a role in many stages of the viral lifecycle, including entry.
Reovirus, a model system for studying the entry mechanisms of nonenveloped viruses …

The mammalian orthoreovirus (reovirus) outer capsid is composed of 200 μ1-σ3
heterohexamers and a maximum of 12 σ1 trimers. During cell entry, σ3 is degraded by …

Background Grass carp reovirus (GCRV), which causes severe infectious outbreaks of
hemorrhagic disease in aquatic animals, is a highly pathogenic agent in the Aquareovirus …