Nucleic acids, including deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are
natural biopolymers composed of nucleotides that store, transmit, and express genetic …

Although various functions of RNA are carried out in conjunction with proteins, some
catalytic RNAs, or ribozymes, which contribute to a range of cellular processes, require little …

The blooming field of structural DNA nanotechnology harnessing the material properties of
nucleic acids has attracted widespread interest. The exploitation of the precise and …

Background: Several types of RNA enzymes (ribozymes) have been identified in biological
systems and generated in the laboratory. Considering the variety of known RNA enzymes …

Addressing the emergence of life from a systems biology perspective, this new edition has
undergone extensive revision, reflecting changes in scientific understanding and evolution …

In vitro mutagenesis of sequences required for the self-catalysed cleavage of a plant virus
satellite RNA has allowed definition of an RNA segment with endoribonuclease activity …

The hammerhead ribozyme is a small catalytic RNA motif made up of three base-paired
stems and a core of highly conserved, non-complementary nucleotides essential for …

Metal ions are required for the growth of all life forms. 1-4 Currently, about half of all proteins
contain metal ions, 5 and most ribozymes cannot function without metal ion (s). 1-3, 6-11 …

▪ Abstract The past few years have seen exciting advances in understanding the structure
and function of catalytic RNA. Crystal structures of several ribozymes have provided detailed …

We have identified a group of DNA molecules that bind to platelet-derived growth factor
(PDGF)-AB with subnanomolar affinity from a randomized DNA library using in vitro …