[HTML][HTML] The Neurodegenerative Elderly Syndrome (NES) hypothesis: Alzheimer and Parkinson are two faces of the same disease

D Caligiore, F Giocondo, M Silvetti - IBRO Neuroscience Reports, 2022 - Elsevier
Increasing evidence suggests that Alzheimer's disease (AD) and Parkinson's disease (PD)
share monoamine and alpha-synuclein (αSyn) dysfunctions, often beginning years before …

The Interplay of Mitochondrial Bioenergetics and Dopamine Agonists as an Effective Disease-Modifying Therapy for Parkinson's Disease

Neha, I Mazahir, SA Khan, P Kaushik, S Parvez - Molecular Neurobiology, 2024 - Springer
Parkinson's disease (PD) is a progressive neurological ailment with a slower rate of
advancement that is more common in older adults. The biggest risk factor for PD is getting …

Air Pollution and Parkinson Disease in a Population-Based Study

B Krzyzanowski, AF Mullan, P Turcano… - JAMA Network …, 2024 - jamanetwork.com
Importance The role of air pollution in risk and progression of Parkinson disease (PD) is
unclear. Objective To assess whether air pollution is associated with increased risk of PD …

A dynamical model for the basal ganglia-thalamo-cortical oscillatory activity and its implications in Parkinson's disease

EM Navarro-Lopez, U Çelikok, NS Şengör - Cognitive Neurodynamics, 2021 - Springer
We propose to investigate brain electrophysiological alterations associated with Parkinson's
disease through a novel adaptive dynamical model of the network of the basal ganglia, the …

Perspective on investigation of neurodegenerative diseases with neurorobotics approaches

S Tolu, B Strohmer, O Zahra - Neuromorphic Computing and …, 2023 - iopscience.iop.org
Neurorobotics has emerged from the alliance between neuroscience and robotics. It
pursues the investigation of reproducing living organism-like behaviors in robots by means …

[HTML][HTML] Unraveling sex differences in Parkinson's disease through explainable machine learning

G Angelini, A Malvaso, A Schirripa, F Campione… - Journal of the …, 2024 - Elsevier
Sex differences affect Parkinson's disease (PD) development and manifestation. Yet, current
PD identification and treatments underuse these distinctions. Sex-focused PD literature often …

[HTML][HTML] Multiple checkpoints of protein clearance machinery are modulated by a common microRNA, miR-4813-3p, through its putative target genes: Studies …

A Sarkar, L Kumar, R Hameed, A Nazir - Biochimica et Biophysica Acta …, 2022 - Elsevier
In order to maintain cellular homeostasis and a healthy state, aberrant and aggregated
proteins are to be recognized and rapidly cleared from cells. Parkinson's disease, known to …

Increasing serotonin to reduce parkinsonian tremor

D Caligiore, F Montedori, S Buscaglione… - Frontiers in Systems …, 2021 - frontiersin.org
While current dopamine-based drugs seem to be effective for most Parkinson's disease (PD)
motor dysfunctions, they produce variable responsiveness for resting tremor. This lack of …

Neurorobotic models of neurological disorders: a mini review

S Pronin, L Wellacott, J Pimentel, RC Moioli… - Frontiers in …, 2021 - frontiersin.org
Modeling is widely used in biomedical research to gain insights into pathophysiology and
treatment of neurological disorders but existing models, such as animal models and …

A biologically constrained spiking neural network model of the primate basal ganglia with overlap** pathways exhibits action selection

B Girard, J Lienard, CE Gutierrez… - European Journal of …, 2021 - Wiley Online Library
Action selection has been hypothesized to be a key function of the basal ganglia, yet the
nuclei involved, their interactions and the importance of the direct/indirect pathway …