The role of human aldehyde dehydrogenase in normal and cancer stem cells

I Ma, AL Allan - Stem cell reviews and reports, 2011 - Springer
Normal stem cells and cancer stem cells (CSCs) share similar properties, in that both have
the capacity to self-renew and differentiate into multiple cell types. In both the normal stem …

Mesenchymal stem cells for the sustained in vivo delivery of bioactive factors

T Meyerrose, S Olson, S Pontow, S Kalomoiris… - Advanced drug delivery …, 2010 - Elsevier
Mesenchymal stem cells (MSC) are a promising tool for cell therapy, either through direct
contribution to the repair of bone, tendon and cartilage or as an adjunct therapy through …

Aldehyde dehydrogenase 1 is a tumor stem cell-associated marker in lung cancer

F Jiang, Q Qiu, A Khanna, NW Todd, J Deepak… - Molecular cancer …, 2009 - AACR
Tumor contains small population of cancer stem cells (CSC) that are responsible for its
maintenance and relapse. Analysis of these CSCs may lead to effective prognostic and …

High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability

AK Croker, D Goodale, J Chu… - Journal of cellular …, 2009 - Wiley Online Library
Cancer stem cells (CSCs) have recently been identified in leukaemia and solid tumours;
however, the role of CSCs in metastasis remains poorly understood. This dearth of …

[HTML][HTML] ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients' outcome

T Li, Y Su, Y Mei, Q Leng, B Leng, Z Liu, SA Stass… - Laboratory …, 2010 - Elsevier
Prostate cancer (PCa) contains a small population of cancer stem cells (CSCs) that
contribute to its initiation and progression. The development of specific markers for …

Aldehyde dehydrogenase 1 A1–positive cell population is enriched in tumor-initiating cells and associated with progression of bladder cancer

Y Su, Q Qiu, X Zhang, Z Jiang, Q Leng, Z Liu… - … Biomarkers & Prevention, 2010 - AACR
Abstract Aldehyde dehydrogenase 1 A1 (ALDH1A1) has recently been suggested as a
marker for cancer stem or stem-like cancer cells of some human malignancies. The purpose …

ALDH1A1 defines invasive cancer stem-like cells and predicts poor prognosis in patients with esophageal squamous cell carcinoma

L Yang, Y Ren, X Yu, F Qian, BSJ Bian, H **ao… - Modern …, 2014 - nature.com
Invasion and metastasis are the major cause of deaths in patients with esophageal cancer.
In this study, we isolated cancer stem-like cells from an esophageal squamous cell …

Enzyme targeting strategies for prevention and treatment of cancer: Implications for cancer therapy

MH Baig, M Adil, R Khan, S Dhadi, K Ahmad… - Seminars in cancer …, 2019 - Elsevier
Extensive growth of cancer in humans is a major cause of death. Numerous studies are
being conducted to improve the early diagnosis, prevention, and treatment of cancer. Recent …

COX-2 induces breast cancer stem cells via EP4/PI3K/AKT/NOTCH/WNT axis

M Majumder, X **n, L Liu, E Tutunea-Fatan… - Stem Cells, 2016 - academic.oup.com
Cancer stem-like cells (SLC) resist conventional therapies, necessitating searches for SLC-
specific targets. We established that cyclo-oxygenase (COX)-2 expression promotes human …

Transplant outcomes in mucopolysaccharidoses

VK Prasad, J Kurtzberg - Seminars in hematology, 2010 - Elsevier
The mucopolysaccharidoses (MPSs) are inherited metabolic disorders (IMDs) caused by
single-gene defects leading to progressive cellular accumulation of glycosaminoglycans …