Late-stage functionalization (LSF) constitutes a powerful strategy for the assembly or
diversification of novel molecular entities with improved physicochemical or biological …

From the start of a synthetic chemist's training, experiments are conducted based on recipes
from textbooks and manuscripts that achieve clean reaction outcomes, allowing the scientist …

There is considerable interest in screening ultralarge chemical libraries for ligand discovery,
both empirically and computationally,,–. Efforts have focused on readily synthesizable …

Bicyclobutanes are among the most highly strained isolable organic compounds and their
associated low activation barriers to reactivity make them intriguing building-blocks in …

Over the past decade, the landscape of molecular synthesis has gained major impetus by
the introduction of late-stage functionalization (LSF) methodologies. C–H functionalization …

In the pursuit of new pharmaceuticals and agrochemicals, chemists in the life science
industry require access to mild and robust synthetic methodologies to systematically modify …

Polymers are ubiquitous to almost every aspect of modern society and their use in medical
products is similarly pervasive. Despite this, the diversity in commercial polymers used in …

Pyridine-based ring systems are one of the most extensively used heterocycles in the field of
drug design, primarily due to their profound effect on pharmacological activity, which has led …

In the past two decades, the world has faced several infectious disease outbreaks. Ebola,
Influenza A (H1N1), SARS, MERS, and Zika virus have had a massive global impact in terms …

The coupling of carboxylic acids and amines to form amide linkages is the most commonly
performed reaction in the pharmaceutical industry. Herein, we report a new strategy that …