The blood–brain barrier: Structure, regulation and drug delivery

D Wu, Q Chen, X Chen, F Han, Z Chen… - Signal transduction and …, 2023 - nature.com
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …

[HTML][HTML] Nanoparticle-based delivery systems for vaccines

R Bezbaruah, VP Chavda, L Nongrang, S Alom… - Vaccines, 2022 - mdpi.com
Vaccination is still the most cost-effective way to combat infectious illnesses. Conventional
vaccinations may have low immunogenicity and, in most situations, only provide partial …

Polymeric in situ forming depots for long-acting drug delivery systems

AK Pandya, LK Vora, C Umeyor, D Surve… - Advanced Drug Delivery …, 2023 - Elsevier
Polymeric in situ forming depots have emerged as highly promising drug delivery systems
for long-acting applications. Their effectiveness is attributed to essential characteristics such …

Research progress in brain-targeted nasal drug delivery

Q Huang, X Chen, S Yu, G Gong, H Shu - Frontiers in Aging …, 2024 - frontiersin.org
The unique anatomical and physiological connections between the nasal cavity and brain
provide a pathway for bypassing the blood–brain barrier to allow for direct brain-targeted …

Phytoestrogens: Chemistry, potential health benefits, and their medicinal importance

VP Chavda, AZ Chaudhari, PC Balar… - Phytotherapy …, 2024 - Wiley Online Library
Phytoestrogens, also known as xenoestrogens, are secondary metabolites derived from
plants that have similar structures and biological effects as human estrogens. These …

Nasal delivery to the brain: harnessing nanoparticles for effective drug transport

S Gandhi, DH Shastri, J Shah, AB Nair, S Jacob - Pharmaceutics, 2024 - mdpi.com
The nose-to-brain drug-delivery system has emerged as a promising strategy to overcome
the challenges associated with conventional drug administration for central nervous system …

The management of Parkinson's disease: an overview of the current advancements in drug delivery systems

DD Nakmode, CM Day, Y Song, S Garg - Pharmaceutics, 2023 - mdpi.com
Parkinson's disease (PD) has significantly affected a large proportion of the elderly
population worldwide. According to the World Health Organization, approximately 8.5 million …

Integration of miRNA's theranostic potential with nanotechnology: promises and challenges for Parkinson's disease therapeutics

KP Tryphena, G Singh, N Jain, P Famta… - Mechanisms of Ageing …, 2023 - Elsevier
Despite the wide research going on in Parkinson's disease (PD), the burden of PD still
remains high and continues to increase. The current drugs available for the treatment of PD …

The optimization design of macrophage membrane camouflaging liposomes for alleviating ischemic stroke injury through intranasal delivery

T Liu, Y Wang, M Zhang, J Zhang, N Kang… - International Journal of …, 2024 - mdpi.com
Ischemic stroke is associated with a high mortality rate, and effective treatment strategies are
currently lacking. In this study, we aimed to develop a novel nano delivery system to treat …

Advanced particulate carrier-mediated technologies for nasal drug delivery

VP Chavda, G Jogi, N Shah, MN Athalye… - Journal of Drug Delivery …, 2022 - Elsevier
Nasal drug delivery has been employed as an alternate and convenient route for the
systemic availability of pharmaceuticals, particularly for potent therapeutics. This is owing to …