Advancing the use of genome-wide association studies for drug repurposing
Genome-wide association studies (GWAS) have revealed important biological insights into
complex diseases, which are broadly expected to lead to the identification of new drug …
complex diseases, which are broadly expected to lead to the identification of new drug …
The state of our understanding of the pathophysiology and optimal treatment of depression: glass half full or half empty?
CB Nemeroff - American Journal of Psychiatry, 2020 - Am Psychiatric Assoc
Major depressive disorder is a remarkably common and often severe psychiatric disorder
associated with high levels of morbidity and mortality. Patients with major depression are …
associated with high levels of morbidity and mortality. Patients with major depression are …
Uncovering the hidden risk architecture of the schizophrenias: confirmation in three independent genome-wide association studies
Objective: The authors sought to demonstrate that schizophrenia is a heterogeneous group
of heritable disorders caused by different genotypic networks that cause distinct clinical …
of heritable disorders caused by different genotypic networks that cause distinct clinical …
The complex genetics and biology of human temperament: a review of traditional concepts in relation to new molecular findings
Recent genome-wide association studies (GWAS) have shown that temperament is strongly
influenced by more than 700 genes that modulate associative conditioning by molecular …
influenced by more than 700 genes that modulate associative conditioning by molecular …
Uncovering the complex genetics of human character
Abstract Human personality is 30–60% heritable according to twin and adoption studies.
Hundreds of genetic variants are expected to influence its complex development, but few …
Hundreds of genetic variants are expected to influence its complex development, but few …
Uncovering the complex genetics of human temperament
Experimental studies of learning suggest that human temperament may depend on the
molecular mechanisms for associative conditioning, which are highly conserved in animals …
molecular mechanisms for associative conditioning, which are highly conserved in animals …
Gene expression networks regulated by human personality
Genome-wide association studies of human personality have been carried out, but
transcription of the whole genome has not been studied in relation to personality in humans …
transcription of the whole genome has not been studied in relation to personality in humans …
Three genetic–environmental networks for human personality
Phylogenetic, developmental, and brain-imaging studies suggest that human personality is
the integrated expression of three major systems of learning and memory that regulate (1) …
the integrated expression of three major systems of learning and memory that regulate (1) …
Deep learning in omics data analysis and precision medicine
The rise of omics techniques has resulted in an explosion of molecular data in modern
biomedical research. Together with information from medical images and clinical data, the …
biomedical research. Together with information from medical images and clinical data, the …
Temperament & Character account for brain functional connectivity at rest: A diathesis-stress model of functional dysregulation in psychosis
The human brain's resting-state functional connectivity (rsFC) provides stable trait-like
measures of differences in the perceptual, cognitive, emotional, and social functioning of …
measures of differences in the perceptual, cognitive, emotional, and social functioning of …