β-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment

PA Halban, KS Polonsky, DW Bowden… - The Journal of …, 2014 - academic.oup.com
OBJECTIVE: This article examines the foundation of β-cell failure in type 2 diabetes (T2D)
and suggests areas for future research on the underlying mechanisms that may lead to …

Combined diet and physical activity promotion programs to prevent type 2 diabetes among persons at increased risk: a systematic review for the Community …

EM Balk, A Earley, G Raman, EA Avendano… - Annals of internal …, 2015 - acpjournals.org
Background: Trials have shown efficacy of rigorous diet and physical activity promotion
programs to reduce diabetes incidence and improve glycemic measures in adults at …

Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline

RS Legro, SA Arslanian, DA Ehrmann… - The Journal of …, 2013 - academic.oup.com
Objective: The aim was to formulate practice guidelines for the diagnosis and treatment of
polycystic ovary syndrome (PCOS). Participants: An Endocrine Society-appointed Task …

Effect of regression from prediabetes to normal glucose regulation on long-term reduction in diabetes risk: results from the Diabetes Prevention Program Outcomes …

L Perreault, Q Pan, KJ Mather, KE Watson… - The Lancet, 2012 - thelancet.com
Background Our objective was to quantify and predict diabetes risk reduction during the
Diabetes Prevention Program Outcomes Study (DPPOS) in participants who returned to …

Therapeutic use of metformin in prediabetes and diabetes prevention

U Hostalek, M Gwilt, S Hildemann - Drugs, 2015 - Springer
People with elevated, non-diabetic, levels of blood glucose are at risk of progressing to
clinical type 2 diabetes and are commonly termed 'prediabetic'. The term prediabetes …

Cardiovascular and renal burdens of prediabetes in the USA: analysis of data from serial cross-sectional surveys, 1988–2014

MK Ali, KMK Bullard, S Saydah… - The lancet Diabetes & …, 2018 - thelancet.com
Background There is controversy over the usefulness of prediabetes as a diagnostic label.
Using data from US National Health and Nutrition Examination Surveys (NHANES) between …

The association of body mass index with the risk of type 2 diabetes: a case–control study nested in an electronic health records system in the United States

ML Ganz, N Wintfeld, Q Li, V Alas, J Langer… - Diabetology & metabolic …, 2014 - Springer
Objectives Obesity is a known risk factor for type 2 diabetes (T2D). We conducted a case–
control study to assess the association between body mass index (BMI) and the risk of being …

Interventions for reversing prediabetes: a systematic review and meta-analysis

KI Galaviz, K Suvada, R Merchant… - American journal of …, 2022 - Elsevier
Introduction Several interventions have been found to be effective for reversing prediabetes
in adults. This systematic review and meta-analysis aims to compare the effectiveness of …

Different effects of lifestyle intervention in high-and low-risk prediabetes: results of the randomized controlled prediabetes lifestyle intervention study (PLIS)

A Fritsche, R Wagner, M Heni, K Kantartzis… - Diabetes, 2021 - Am Diabetes Assoc
Lifestyle intervention (LI) can prevent type 2 diabetes, but response to LI varies depending
on risk subphenotypes. We tested whether individuals with prediabetes with low risk (LR) …

Changes in glucose metabolism and glycemic status with once-weekly subcutaneous semaglutide 2.4 mg among participants with prediabetes in the STEP program

L Perreault, M Davies, JP Frias, PN Laursen… - Diabetes …, 2022 - Am Diabetes Assoc
OBJECTIVE This analysis of 3,375 adults with overweight/obesity across the Semaglutide
Treatment Effect in People with obesity (STEP) 1, 3, and 4 trials evaluated whether more …