Tetrahydrofolate (THF) polyglutamates are a family of cofactors that carry and chemically
activate one‐carbon units for biosynthesis. THF‐mediated one‐carbon metabolism is a …

Recent structural data and the properties of several active site mutants of serine
hydroxymethyltransferase have resolved some key questions concerning the catalytic …

RNA can directly control protein activity in a process called riboregulation; only a few
mechanisms of riboregulation have been described in detail, none of which have been …

The de novo thymidylate biosynthetic pathway in mammalian cells translocates to the
nucleus for DNA replication and repair and consists of the enzymes serine …

Abstract Serine hydroxymethyltransferase 2 (SHMT2) regulates one-carbon transfer
reactions that are essential for amino acid and nucleotide metabolism, and uses pyridoxal …

The hydroxymethyl group of serine is a primary source of tetrahydrofolate (THF)-activated
one-carbon units that are required for the synthesis of purines and thymidylate and for S …

Adaptive metabolic reprogramming gives cancer cells a proliferative advantage. Tumour
cells extensively use glycolysis to sustain anabolism and produce serine, which not only …

The increasing availability of experimental and computational protein structures entices their
use for function prediction. Here we develop an automated procedure to identify enzymes …

Deubiquitinating enzymes (DUBs) are a group of proteases that are important for
maintaining cell homeostasis by regulating the balance between ubiquitination and …

The catalytic potential for H2S biogenesis and homocysteine clearance converge at the
active site of cystathionine β-synthase (CBS), a pyridoxal phosphate-dependent enzyme …