Thyroid hormones are crucial for organismal development and homeostasis. In humans,
untreated congenital hypothyroidism due to thyroid agenesis inevitably leads to cretinism …

Pancreas oganogenesis comprises a coordinated and highly complex interplay of signaling
events and transcriptional networks that guide a step‐wise process of organ development …

Organogenesis is a complex and interconnected process that is orchestrated by multiple
boundary tissue interactions,,,,,–. However, it remains unclear how individual, neighbouring …

Visceral organs, such as the lungs, stomach and liver, are derived from the fetal foregut
through a series of inductive interactions between the definitive endoderm (DE) and the …

Type 2 diabetes mellitus results from the interaction of environmental factors with a
combination of genetic variants, most of which were hitherto unknown. A systematic search …

Identifying the genetic variants that increase the risk of type 2 diabetes (T2D) in humans has
been a formidable challenge. Adopting a genome-wide association strategy, we genotyped …

The molecular mechanisms involved in the development of type 2 diabetes are poorly
understood. Starting from genome-wide genotype data for 1924 diabetic cases and 2938 …

The endoderm germ layer contributes to the respiratory and gastrointestinal tracts and to all
of their associated organs. Over the past decade, studies in vertebrate model organisms …

Embryonic development of the liver has been studied intensely, yielding insights that impact
diverse areas of developmental and cell biology. Understanding the fundamental …

Hepatocytes, like other epithelia, are situated at the interface between the organism's
exterior and the underlying internal milieu and organize the vectorial exchange of …