Neurodegenerative diseases affect not only the life quality of aging populations, but also
their life spans. All forms of neurodegenerative diseases have a massive impact on the …

Adenosine signalling has long been a target for drug development, with adenosine itself or
its derivatives being used clinically since the 1940s. In addition, methylxanthines such as …

Neurodegenerative diseases (NDs) including Alzheimer's disease, Parkinson's disease,
amyotrophic lateral sclerosis, and Huntington's disease are incurable and affect millions of …

In modern societies, with an increase in the older population, age-related
neurodegenerative diseases have progressively become greater socioeconomic burdens …

Abstract Adenosine A 2A receptor (A 2A R) is a G-protein-coupled receptor highly expressed
in basal ganglia. Its expression levels are severely reduced in Huntington's disease (HD) …

Huntington's disease (HD), a neurodegenerative disease, normally starts in the prime of
adult life, followed by a gradual occurrence of characteristic psychiatric disturbances and …

Adenosine receptors are P1 class of purinergic receptors that belong to G protein‐coupled
receptors. There are 4 subtypes of adenosine receptors, namely A1, A2A, A2B, and A3 …

Unlike many other neurodegenerative diseases with established gene–environment
interactions, Huntington's disease (HD) is viewed as a disorder governed by genetics. The …

Abstract Adenosine A 2A receptor (A 2A R) is a G-protein coupled receptor that regulates
several important functions in the central nervous system. Large amount of preclinical data …

Huntington's disease (HD) is a rare and fatal neurodegenerative disorder with no
diseasemodifying therapeutics. HD is characterized by extensive neuronal loss and is …